Project Grant R01EY038779
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Johns Hopkins University a $695,018 Project Grant effective August 1, 2025, through July 31, 2030, to conduct research on the regulation of retinal ganglion cell regeneration through Müller glia (MG) cell function. The award supports a five-year investigation into how MG cells function as injury-responsive stem cells to enable retinal regeneration, with the ultimate goal...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Johns Hopkins University a Project Grant totaling $836,776 under the Vision Research program (CFDA 93.867), effective September 1, 2025 through August 31, 2027. This award supports research establishing the ferret as a new animal model for studying amblyopia, the leading cause of poor vision in infants and children. The project addresses a critical gap in understanding how amblyopia—caused by strabismus, anisometropia, or...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded The Johns Hopkins University a Project Grant of $223,248 on September 15, 2025, for research on photoreceptor patterning in flies and mosquitoes through August 31, 2027. This award supports fundamental research aimed at advancing understanding of cell fate specification and sensory neuron differentiation during eye development. The primary research product consists of scientific...
- Federal Grant Award Summary Johns Hopkins University received a $621,250 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) on September 15, 2025, with a completion date of August 31, 2027. The project, titled "Gaze-Contingent AI-Enabled Low Vision Assistive Technology (GALVAT)," will develop smart assistive technology designed to address information overload challenges in vision loss rehabilitation devices. The research...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Washington University a $1,001,009 Project Grant under the Vision Research program (CFDA 93.867) effective July 1, 2025, with a completion date of March 31, 2030. This grant supports fundamental research investigating visual feature competition between central and peripheral retinal pathways—specifically, how eye fixation signals and optokinetic reflex (OKR) signals interact within the retina. The research aims to advance...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded The Medical College of Wisconsin, Inc. a Project Grant of $856,698 effective July 1, 2025, through March 31, 2030. This award funds mechanistic research into retinal ganglion cell (RGC) genesis, with the overarching goal of understanding the developmental factors required to generate RGCs in vitro for potential cell transplantation therapies and regenerative treatments for...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded Columbia University a $100,228 Project Grant under the Vision Research program (CFDA 93.867) effective December 1, 2026, through April 29, 2029, to develop and validate autologous induced pluripotent stem cell (iPSC) transplantation as a therapeutic approach for autosomal dominant retinal disorders, specifically those caused by the RPE65 D477G mutation. The research addresses a critical gap in gene therapy for dominant...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $830,024 to the University of Colorado-Denver for a two-year project (September 1, 2025 – August 31, 2027) titled "Elucidating Competence and Fate Choice Dynamics During Retinal Development." This research project will produce fundamental scientific findings and empirical data aimed at understanding how the Notch signaling pathway regulates cell fate specification...
- Federal Grant Award Summary The University of Chicago received a $902,000 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded on September 1, 2025, with a completion date of August 31, 2027. This grant supports the development of the RGC (Retinal Ganglion Cell) Projectome, a comprehensive research initiative aimed at understanding how hundreds of thousands of retinal ganglion cell axons accurately grow toward the brain during embryogenesis...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant totaling $545,948 under the Vision Research program (CFDA 93.867) for the period April 1, 2026 through March 31, 2030. The research project, "Understanding the Role of Reactive Astrocytes in Glaucoma," will generate fundamental scientific knowledge regarding the mechanisms by which astrocytes—the primary non-neuronal cells in the optic nerve...
The National Eye Institute (NEI) awarded The Johns Hopkins University a $682,679 Project Grant effective July 1, 2026, through January 31, 2030, under the Vision Research program (CFDA 93.867). The award funds research titled "Identifying Drivers of Retinal Ganglion Cell Differentiation from Endogenous Stem Cells," which aims to characterize the regenerative mechanisms underlying retinal ganglion cell (RGC) production in zebrafish models. The research deliverables include detailed characterization of RGC regeneration processes, identification of cellular and molecular cues regulating RGC regeneration from multiple stem cell pools, and discovery of factors that drive RGC differentiation independent of cell loss—findings intended to establish a translational roadmap for developing therapies to reverse optic nerve damage and treat blindness in humans. This fundamental research initiative addresses a critical gap in vision science by leveraging zebrafish's natural capacity for complete optic nerve regeneration to understand mechanisms absent or dormant in mammalian systems. The research products will contribute empirical findings and mechanistic insights that support the development of therapeutic interventions for retinal ganglion cell loss, a condition currently lacking effective treatments beyond protective approaches. Performance occurs at Johns Hopkins' Baltimore, Maryland facility.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $682.7k | 6/11/26 |