Project Grant R01EY038207
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute Inc. a Project Grant of $1.79 million under the Vision Research program (CFDA 93.867) to investigate non-invasive transpalpebral electrical stimulation (TPES) as a therapeutic intervention for diabetic keratopathy (DK). The two-year project, commencing September 1, 2025 and concluding August 31, 2027, will deliver scientific research products including empirical findings on the mechanisms...
- Federal Grant Award Summary Wayne State University received a $1.19M Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2025 through February 28, 2029. The award funds research investigating a peptide-based combination therapy (TB4/VIP) designed to restore structure and function in diabetic corneas by targeting hyperglycemia-responsive cellular circuits. The research addresses a significant clinical gap, as current treatment...
- Federal Grant Award Summary New York University School of Medicine received a $546,439 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with completion anticipated by March 31, 2030. The award funds research to develop corneal stromal keratocyte modeling from human cornea organoids (HCOs) as a potential therapy for corneal scarring and keratoconus-related blindness. The research leverages HCOs generated from induced...
- Federal Project Grant Award Summary The Doheny Eye Institute received a $3,046,866 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through August 31, 2028. The award funds research on the mechanobiology of retinal vascular inflammation and degeneration in diabetic retinopathy (DR), a leading cause of vision loss in the working-age population. The research aims to deliver empirical findings and therapeutic insights...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant totaling $540,213 under the Vision Research program (CFDA 93.867) to investigate the fibrosis-immunity interface in corneal transplantation. Beginning August 1, 2025, and extending through July 31, 2030, this research program will deliver scientific findings aimed at improving corneal transplant survival rates by elucidating the mechanisms by which myofibroblasts...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant totaling $900,600 to The Regents of the University of California, San Francisco, with an award date of September 1, 2025, and completion date of August 31, 2027, under the Vision Research program (CFDA 93.867). This award funds research directed at understanding corneal limbal stem cells (LSCs) during wound healing processes. The project addresses the significant clinical need for restorative treatments for...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $255,722 under the Vision Research program (CFDA 93.867) to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027. This Project Grant supports fundamental research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The research deliverables include scientific findings on how lipoxin B4 (LXB4), an endogenous lipoxin produced by retinal...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a three-year Project Grant totaling $2,674,763 to Centre Hospitalier De L'Université De Montréal (CHUM) beginning September 30, 2025, with completion targeted for September 29, 2028. This award funds research investigating interpericyte tunneling nanotubes (IPTNTs) as therapeutic targets for glaucoma treatment and vision restoration. The research will generate empirical findings...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded University of California, Irvine $179,964 under the Vision Research program (CFDA 93.867) on March 1, 2025, for a project grant extending through July 10, 2029. The project focuses on developing deep learning-based biomarkers for optic neuropathies using retinal Optical Coherence Tomography (OCT) imaging analysis. The research will employ advanced computational techniques, including deep generative models, neural field image...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $144,618 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through March 31, 2028. The grant funds research investigating fucosylation as a mediator of limbal stem cell (LSC) viability. The research focuses on understanding how fucose, a monosaccharide component of the cell surface glycocalyx, influences the survival of limbal stem...
The National Eye Institute (NEI) awarded a Project Grant of $497,740 to the University of Illinois (Chicago, IL) under the Vision Research program (CFDA 93.867), effective April 1, 2026, through March 31, 2031. Under the direction of Principal Investigator Elmira Jalilian, this research project will generate scientific findings and empirical data examining neuro-epithelial interactions in corneal disease and repair, with particular focus on how corneal nerves communicate with corneal epithelial cells through extracellular vesicles (EVs). The project addresses diabetic corneal neuropathy, a complication affecting approximately 50% of diabetes mellitus patients that impairs corneal healing and epithelial homeostasis. The research will produce fundamental knowledge regarding the mechanisms by which trigeminal nerve-derived extracellular vesicles regulate corneal epithelial cell proliferation, migration, and adhesion—processes essential for corneal repair. Preliminary findings indicate that nerve-derived EVs generate distinct transcriptional programs in corneal epithelial cells that differ from mesenchymal stem cell-derived EV treatments. Deliverables will include peer-reviewed research publications, in vitro experimental data, and sequencing analyses that clarify the neuronal contribution to corneal health, potentially informing future therapeutic strategies for vision-threatening corneal complications in diabetic patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $497.7k | 4/2/26 |