Project Grant R01EY037294
- The National Eye Institute (part of the Department of Health and Human Services National Institutes of Health) awarded West Virginia University Research Corporation $2.739 million on September 15, 2025, under the Vision Research program (CFDA 93.867) to develop therapies for photoreceptor outer segment defects associated with blinding diseases. The research identifies and develops therapeutic interventions for defects in protein networks essential to photoreceptor outer segment morphogenesis....
- The National Eye Institute awarded West Virginia University Research Corporation $420,750 on June 1, 2026, under the Vision Research program (CFDA 93.867) to develop a novel fluorescence-based pulse-chase labeling technique combined with super-resolution microscopy for tracking protein trafficking dynamics in mouse rod photoreceptor neurons. The research addresses knowledge gaps in mammalian photoreceptor cell biology by using SNAP-TAG technology to label nascent photoreceptor proteins and...
- The National Eye Institute awarded West Virginia University Research Corporation $420,750 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate molecular regulators of cone opsin trafficking in the retina. The recipient will identify, characterize, and validate novel OPN1MW (medium-wavelength cone opsin) trafficking partners using two innovative knock-in mouse models. In the first aim, researchers will use OPN1MW.ALFA knock-in mice to isolate stable, direct opsin...
- The National Eye Institute awarded West Virginia University Research Corporation $146,541 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the interplay of hemodynamic and biomechanical factors in glaucoma pathophysiology using integrated ultrasound imaging methods. The project integrates super-resolution ultrasound localization microscopy with ultrasound elastography strain tracking in a small animal model to examine how systemic and ocular hemodynamics...
- The National Eye Institute awarded the University of Pennsylvania $674,423 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of retinal microsomal triglyceride transfer protein (MTP) in vision and lipid homeostasis. The research examines how MTP regulates the assembly and secretion of apoprotein B-containing lipoproteins in the retinal pigment epithelium (RPE), which transport lipids and prevent pathologic lipid accumulation linked to retinal...
- The National Eye Institute awarded The Research Foundation For The State University Of New York $248,737 on June 1, 2026, under the Vision Research program (CFDA 93.867) to support research on the role of mitochondrial and autophagy dysfunction in regulating inflammatory processes during age-related macular degeneration pathogenesis. The award funds investigation into the deregulation of autophagy and heightened inflammation implicated in dry AMD, the leading cause of blindness in the elderly...
- The National Institutes of Health National Eye Institute awarded a $1.792 million Cooperative Agreement to the University of California, Los Angeles on September 1, 2026, under the Vision Research program (CFDA 93.867). The award funds development of adeno-associated virus vectors incorporating cell-type-specific cis-regulatory modules to target 23 distinct retinal cell types in primates, enabling precise labeling and functional manipulation of specific cells. The project aims to dissect...
- The National Eye Institute awarded the Regents of the University of Michigan $519,644 on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the metabolic and molecular mechanisms by which glutamine promotes photoreceptor health and survival. The research addresses photoreceptor death as a cause of vision loss in retinal diseases. The recipient's work defines the downstream metabolic and molecular pathways by which glutamine catabolism impacts rod photoreceptor health,...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $624,743 to the Regents of the University of California, doing business as University of California, Berkeley, on May 1, 2026, under the Vision Research program (CFDA 93.867). The award funds research into the function and regulation of constitutive prostaglandin D2 and DP receptor signaling in retinal health and neurodegeneration. The research investigates the physiological and...
- The National Eye Institute awarded The Methodist Hospital Research Institute $1,029,472 on May 1, 2026, under the Vision Research program (CFDA 93.867) to develop mitochondrial-based cell therapy for age-related macular degeneration. The recipient will create a sustainable source of mitochondria proximal to the retinal pigment epithelium using mesenchymal stem cells transfected with nuclear respiratory factor 1 (NRF1), a driver of mitochondrial biogenesis. The work aims to determine how NRF1...
The National Eye Institute awarded West Virginia University Research Corporation $550,584 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the mechanism of nicotinamide mononucleotide adenylyltransferase-1 (NMNAT1) in retinal photoreceptor biogenesis and health. The project addresses why mutations in NMNAT1 cause Leber congenital amaurosis, a severe early-onset blinding disorder. Research will determine whether elevated nicotinamide mononucleotide (NMN) is intrinsically toxic to photoreceptors independent of SARM1, a key pro-degenerative NADase, and will investigate NMNAT1's non-enzymatic functions and compartment-specific roles in maintaining NAD homeostasis. The work seeks to establish a new paradigm for NMNAT1 function in subcellular NAD regulation and reveal novel therapeutic strategies for restoring vision in NMNAT1-associated retinal diseases, with findings intended to guide development of targeted gene therapies for Leber congenital amaurosis. Performance runs from September 1, 2026, through May 31, 2030, at Morgantown, West Virginia. The assistance type is a Project Grant, a single-project research award under the Vision Research program mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $550.6k | 9/2/26 |