Project Grant R01EY037245
- Federal Grant Award Summary The University of Alabama at Birmingham received a $668,581 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2030. This research initiative investigates the role of bacterial-derived metabolites in diabetic retinopathy (DR), with emphasis on tryptophan metabolites generated by the gut microbiome. The project will utilize liquid chromatography-mass spectrometry (LC-MS) for...
- Federal Grant Award Summary Emory University received a $617,201 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective July 1, 2025, through March 31, 2030. The award supports research to understand axonal injury mechanisms in glaucomatous optic neuropathy by leveraging innovative tools from engineering, artificial intelligence (AI), and advanced imaging techniques, specifically optical coherence tomography (OCT). The research aims to...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded Northwestern University a $1.62 million Project Grant on September 1, 2025, to develop computational models and diagnostic tools for improving glaucoma treatment outcomes. The three-year project, extending through August 31, 2028, focuses on modeling aqueous humor outflow based on a digital twin of the anterior eye imaged by robotic optical coherence tomography (OCT). The...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $427,625 under the Vision Research program (CFDA 93.867) to The Washington University for a two-year project (April 1, 2026 – March 31, 2028) to develop novel statistical methodologies for detecting and characterizing visual field progression in primary open-angle glaucoma (POAG). The primary deliverables include: (1) a change-point statistical model integrating longitudinal mean deviation measures to identify early disease...
- Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $417,162 to the University of Houston System for a two-year project (July 1, 2025 – June 30, 2027) investigating the birefringence properties of the lamina cribrosa and posterior eye structures as they relate to glaucoma detection and diagnosis. The project addresses a critical clinical need by developing advanced optical imaging methodologies to detect early structural and stress-related changes...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $764,881 Project Grant to the University of Colorado-Denver on September 15, 2025, to investigate the role of advanced glycation end products (AGEs) in primary open angle glaucoma (POAG). Primary open angle glaucoma is the most common form of glaucoma, accounting for approximately 80% of all glaucoma cases globally and affecting 80 million people, with 11 million...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $902,000 to the University of California, San Francisco for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The primary deliverables include comprehensive phenotypic characterization of GLIS1 knockout mice across two genetic backgrounds, evaluating structural and functional...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $414,711 Project Grant from the National Eye Institute (NEI) Vision Research program (CFDA 93.867), awarded June 1, 2025, with completion targeted for May 31, 2029. The award supports the development and utilization of a microphysiological system to elucidate mechanisms underlying early optic disc and stalk development, retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding in human development and...
- Federal Grant Award Summary Baylor College of Medicine received a $1,093,095 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research program) effective July 1, 2025 through March 31, 2030, to investigate the role of vascular ligands and neurovascular dysfunction in glaucoma pathogenesis and to identify therapeutic targets for neuroprotection. The research leverages an innovative ligandomics technology platform to globally map cell-binding ligands with binding...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant of $545,948 under the Vision Research program (CFDA 93.867) to advance understanding of glaucoma pathophysiology. The award, effective April 1, 2026 through March 31, 2030, supports research investigating the role of reactive astrocytes in glaucoma progression and retinal ganglion cell (RGC) survival. The research aims to move beyond traditional neurocentric...
The University of Alabama at Birmingham received a $636,862 Project Grant from the National Eye Institute's Vision Research program (CFDA 93.867) effective April 1, 2026, through March 31, 2030. This research initiative focuses on developing and validating mechanical, vascular, and morphometric biomarkers to assess individual eye-specific susceptibility to glaucoma onset and progression. The project will deliver longitudinal optical coherence tomography (OCT) imaging data quantifying optic nerve head (ONH) mechanical deformations and vascular perfusion in response to controlled acute intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) elevations in an animal glaucoma model. Deliverables will include strain measurements collected from disease onset through progression endpoints, validated by three-dimensional histologic reconstructions of ONH tissue morphology and architecture. The award will produce computational models of ONH tissues validated against in vivo image-based strain measurements, with anticipated application of artificial intelligence analytical methods to generate clinical biomarkers for early glaucoma diagnosis and individual susceptibility assessment. These research products address a critical gap in the field, as current therapeutic interventions for glaucoma rely solely on IOP reduction without accepted clinical methods for assessing eye-specific susceptibility risk. The project outcomes are intended to inform future clinical assessment protocols for patients with varying individual glaucoma susceptibility thresholds.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $636.9k | 4/2/26 |