The National Eye Institute (NEI) awarded a $360,897 Project Grant (CFDA 93.867 - Vision Research) to Human Cell Co., a for-profit biotechnology research company, with a performance period from September 30, 2024 to August 31, 2025. The grant supports the development and evaluation of a novel combination therapy for glaucoma, involving topical administration of a proprietary nerve growth factor (NGF) mutein, HC201, in conjunction with oral nicotinamide (NAM) supplementation. The key objectives...
The National Eye Institute (NEI) awarded a Project Grant under the Vision Research program (CFDA 93.867) to the University of North Texas Health Science Center at Fort Worth in the amount of $191,095 with a period of performance from September 1, 2024 to August 31, 2026. The purpose of this grant is to investigate how metabolic changes in optic nerve head cells, specifically astrocytes and lamina cribrosa cells, contribute to the development of fibrosis in glaucoma. The research aims to...
The National Eye Institute (NEI) awarded a $2,260,440 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Leland Stanford Junior University. This grant will fund research to establish the molecular, cellular, and transcriptional mechanisms that regulate neurotoxic and protective reactivity of astrocytes in the optic nerve head and Müller glia in a mouse model of glaucoma. The research aims to discover new biological pathways that control glial reactivity in...
The National Eye Institute (NEI) awarded a $248,999 Project Grant (CFDA 93.867 - Vision Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, with a project period from May 1, 2025 to April 30, 2028. The grant supports research to investigate how neuronal synaptic activity, particularly glutamatergic signaling, regulates retinal angiogenesis and blood-retina barrier (BRB) maturation during postnatal development. The research aims to elucidate the...
This $387,428 Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), aims to investigate fundamental mechanisms that drive optic nerve sensitivity to elevated intraocular pressure (IOP), a major risk factor for optic nerve damage in glaucoma. The research will be conducted by The Research Foundation for the State University of New York, doing business as Upstate Medical Center, over a 5-year period from March 1, 2025 to...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides funding for research to understand the role of serotonin (5-HT) and serotonin receptors, particularly the 5-HT1B receptor (HTR1B), in normal retinal ganglion cell (RGC) function and their susceptibility to glaucoma-induced injury. The $1,600,857 award to Baylor College of Medicine aims to: 1) determine the cell-type specific function of HTR1B in the inner retina; 2) elucidate the intracellular...
The National Eye Institute (NEI) has awarded a $234,000 Project Grant (CFDA 93.867 - Vision Research) to Oregon Health & Science University (OHSU) to enhance stem cell restoration of intraocular pressure (IOP) homeostasis through the use of senolytic treatments. The two-year project, running from February 1, 2025 to January 31, 2027, aims to explore the potential of senotherapeutics, including senolytics and senoreverters, to restore IOP homeostatic function in glaucomatous tissue, with or...
This federal Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports research to investigate the role of cyclic guanosine monophosphate (cGMP) signaling in glaucomatous neurodegeneration. The $526,841 award, with a project period from February 1, 2025 to January 31, 2030, is being provided to Vanderbilt University Medical Center (VUMC) to conduct this research. The key objectives are to examine how disrupted cGMP...
The National Eye Institute (NEI) awarded a $423,767 Project Grant under CFDA 93.867 (Vision Research) to the University of California, Davis to support research on the role of myeloid cells in glaucomatous axon degeneration. The research aims to determine whether NAD+-based interventions can protect against axon injury in a glaucoma-relevant model, and to characterize the immune response and test the hypothesis that immune cell invasion is necessary for axon destruction due to NAD+ depletion....
The National Eye Institute (NEI) awarded a $414,711 Project Grant (CFDA 93.867 - Vision Research) to Albert Einstein College of Medicine to establish and utilize a microphysiological system for elucidating the mechanisms underlying early optic disc and stalk development, retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding in human development and the pathogenesis of blinding retinal diseases. The project aims to 1) dissect the mechanisms underlying the specification and...