This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) will support research to establish a chimeric mouse model for studying human retinal microglia in vivo. The $247,700 award, with a project period from February 1, 2025 to January 31, 2027, will enable researchers at the University of Utah to: Characterize the engraftment, density, and distribution of human xenotransplanted microglia (xMGs) in the mouse retina and optic...
The National Eye Institute (NEI) awarded a $2,260,440 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Leland Stanford Junior University. This grant will fund research to establish the molecular, cellular, and transcriptional mechanisms that regulate neurotoxic and protective reactivity of astrocytes in the optic nerve head and Müller glia in a mouse model of glaucoma. The research aims to discover new biological pathways that control glial reactivity in...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports research focused on identifying cellular mechanisms and therapeutic targets for retinopathies caused by ischemia or trauma, including diabetic retinopathy, retinal artery or vein occlusion, and traumatic optic neuropathy. The central hypothesis is that upregulation of the enzyme histone deacetylase 3 (HDAC3) in myeloid cells after retinal injury increases...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will support research to investigate the role of interleukin-6 (IL-6) signaling in the development of diabetic retinopathy. The research aims to: Determine how disruption of the IL-6 "cis-trans balance" in Muller glial cells affects vascular endothelial growth factor (VEGF) expression, leading to oxidative stress and breakdown of the inner blood-retinal...
The National Eye Institute (NEI) awarded a $248,999 Project Grant (CFDA 93.867 - Vision Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, with a project period from May 1, 2025 to April 30, 2028. The grant supports research to investigate how neuronal synaptic activity, particularly glutamatergic signaling, regulates retinal angiogenesis and blood-retina barrier (BRB) maturation during postnatal development. The research aims to elucidate the...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $421,600.00 in funding to Tufts Medical Center to investigate the regulatory mechanisms that govern retinal neovascularization. The research aims to delineate the role of chemokine signaling in facilitating the recruitment of peripheral immune cells and promoting pathological vascular growth, as well as define the impact of microglial complement receptors on neovascular regression. The award...
This Project Grant award from the National Eye Institute (NEI), under the CFDA 93.867 Vision Research program, will support research to investigate changes in rod photoreceptor function and retinal plasticity during the progression of retinal degeneration. The $624,230 award, effective from May 1, 2025 to April 30, 2029, will be conducted by researchers at the University of California, Los Angeles (UCLA). The key objectives of the project are to: 1) Document changes in rod membrane potential,...
This Project Grant award of $400,000 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports a research project led by Northwestern University to investigate the role of retinal perivascular macrophages in the development of diabetic retinopathy and autoimmune uveitis. The key objectives of the five-year project are to: 1) determine the ontological origin and longevity of retinal perivascular macrophages, 2) assess the role of these macrophages in the...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $651,846 to The Johns Hopkins University to identify gene regulatory networks that control the temporal patterning of retinal progenitor cells and neurogenic Müller glia. The research aims to determine the necessary and sufficient transcription factors that specify early versus late-stage retinal progenitor cell identity, and investigate whether these factors can...
The National Eye Institute (NEI) awarded a $1,298,882 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Oklahoma Health Sciences Center to investigate extracellular microRNA-mediated communication between retinal pigment epithelium (RPE) and microglia cells. The primary goals are to study the transfer of extracellular microRNAs between RPE and microglia, and to evaluate the use of engineered RPE-derived extracellular vesicles as an intervention to...
This $606,034 Project Grant, awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research to investigate the role of Müller glia cells in the acute and chronic inflammatory response to stress, injury, and disease in the retina.
The award will enable the development of a detailed profile of the acute inflammatory response in human and mouse retinas across 15 physiologically relevant cellular perturbations, building on the researchers' existing datasets in the Acute Retinal Stress Interactive Portal (ARS-IP) and Murine Retinal Disease Database (MRD-DB). Importantly, the project aims to elucidate the central role of Müller glia in coordinating the inflammatory response and to compare the distinct pathways activated during acute versus chronic retinal inflammation. The research findings will be shared through the St. Jude Cloud to accelerate scientific discoveries related to retinal inflammation and homeostasis. This project, awarded from February 2025 to January 2030, has the potential to provide critical insights into the molecular and cellular mechanisms underlying acute and chronic retinal disease conditions that contribute to human blindness.