Project Grant R01EY037073

Award Date 3/1/25
Completion Date 2/28/30
Dollars Obligated $619K
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Iowa City, IA 52242, USA
Similar Awards
This Project Grant award from the National Eye Institute (NEI), under the CFDA 93.867 Vision Research program, is supporting research on developing universally immune-compatible induced pluripotent stem cells (iPSCs) for regenerative therapies targeting various eye conditions. The $492,500 grant awarded to The Schepens Eye Research Institute, Inc. aims to create iPSC lines that express HLA-I molecules without high-affinity peptides, enabling them to evade both CD8+ T-cell and natural killer...
The National Eye Institute (NEI), through its Vision Research program (CFDA 93.867), awarded a $881,796 Project Grant to Siloam Vision, Inc. to develop two advanced, laser-based, artificial intelligence (AI)-enabled retinal imaging systems. The primary goal is to address the unmet need for cost-effective and less stressful methods to diagnose and monitor retinopathy of prematurity (ROP), a leading cause of childhood blindness. The key innovations include: 1) A wider field-of-view camera design...
This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) aims to develop and evaluate transient intranuclear peptide assemblies (NPAs) to selectively eliminate residual human-induced pluripotent stem cells (iPSCs) in cell mixtures, without impacting iPSC-derived cells. The $193,351 award to Brandeis University, with a performance period from September 30, 2024 to June 30, 2026, will fund research focused on three specific aims: 1)...
This R01 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $1,640,894 to establish feasibility and mechanisms of structural and functional integration of a novel stem cell-derived 3D retinal transplant containing photoreceptors and retinal pigment epithelium (3DNR/RPE) in a minipig model of end-stage macular atrophy. The goal is to address critical gaps in devising cell-based transplantation strategies to jointly regenerate...
The National Eye Institute (NEI) awarded a $477,109 Project Grant (CFDA 93.867 - Vision Research) to the University of Texas Southwestern Medical Center to investigate how the PRDM13 transcriptional regulator influences retinal development and photoreceptor cell fate. The research aims to further the understanding of mammalian retinal development and mechanisms underlying healthy retinogenesis. The project period runs from May 1, 2025 to April 30, 2030. The research will explore how...
This Project Grant award from the National Eye Institute (NEI) under CFDA Program 93.867 (Vision Research) provides $1,173,062 to The University of Iowa to conduct research on how extracellular matrix stiffness and genetic risk factors impact the epithelial-to-mesenchymal transition (EMT) of retinal pigmented epithelial (RPE) and choroidal endothelial cells (ChECs) in the context of age-related macular degeneration (AMD). The research aims to 1) determine how matrix stiffening impacts RPE and...
The National Eye Institute (NEI) awarded a $580,331 Project Grant (CFDA 93.867 - Vision Research) to The Trustees of the Stevens Institute of Technology in Hoboken, New Jersey. The grant funding will support the development of a deep learning-based diagnostic model for retinopathy of prematurity (ROP), a leading cause of childhood blindness globally. The key objectives are to: Optimize and test an animal-to-human (A2H) model using existing retinal image datasets to augment the training data...
This Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems Engineering Directorate will support $541,665 in research at The University of Iowa from October 2022 through September 2026. The grant aims to advance control of human induced pluripotent stem cell differentiation to retinal cells through genomic and microfluidic techniques. Researchers will develop genome-wide methods leveraging cell differentiation properties...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) will support research to elucidate the gene regulatory networks driving neural regeneration in the central nervous system. The overarching objective is to profile changes in gene regulation that cause retinal pigment epithelial (RPE) cells to lose their neural competency as they differentiate. The total funding for this 18-month award is $162,358, with a start date of July 1, 2024 and...
The National Eye Institute (NEI) awarded The Johns Hopkins University a five-year, $651,846 Project Grant under the Vision Research federal grant program (CFDA 93.867) to identify gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Muller glia. The research aims to determine the necessary and sufficient transcription factors that specify early- versus late-stage retinal progenitor cell identity, and investigate how these factors regulate...

The National Eye Institute (NEI) awarded a $618,600 Project Grant (CFDA 93.867 - Vision Research) to the University of Iowa to develop innovative, non-destructive methods for assessing the differentiation capacity and developmental maturity of patient-derived induced pluripotent stem cells (iPSCs) for retinal regenerative therapies. The project aims to train AI algorithms to identify iPSC lines with high retinal differentiation potential, and to correlate imaging data with transcript expression to enable non-destructive assessment of retinal organoid maturity. This will help streamline the manufacturing of autologous iPSC-derived retinal cell therapies by reducing waste and enabling release testing on the final product intended for clinical use. The award period extends from March 1, 2025 to February 28, 2030.

Generated 5/13/25, 2:08 AM