Project Grant R01EY036689

Award Date 8/1/24
Completion Date 3/31/29
Dollars Obligated $1.8M
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Memphis, TN 38105, USA
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The research team at St. Jude Children's Research Hospital, the grant recipient, will test the hypothesis that the SIX3/SIX3 and OTX2/OTX2 genes are regulated by modular super-enhancers in the developing retina. This work will fill a critical gap in understanding how these essential retinal development genes are controlled, and validate a comprehensive genome-wide map of promoter-super-enhancer interactions in the retina developed by the researchers. The findings could provide insights into potential regulatory elements that may contribute to developmental defects in the retina.

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