This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $146,922 to The Johns Hopkins University to conduct research on understanding the chromatin architectural landscape of retinal development at the single-cell level. The key objectives of this research project are to: 1) Capture the 3D chromatin interactions of mouse retinal cells at key developmental stages using single-cell Hi-C (SCHI-C) technology adapted...
This federal Project Grant award, provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), will support research to investigate the genetic and epigenetic mechanisms underlying retinal development and vision disorders. The total funding amount is $1,241,223, with a project period from September 1, 2024 to March 31, 2029. The research aims to provide a deep understanding of the chromatin-based regulatory mechanisms that govern retinal transcription programs...
The National Eye Institute (NEI) awarded a Project Grant under the Vision Research program (CFDA 93.867) to the University of Washington to study how the retina encodes visual information in natural environments with dynamic changes in light intensity. The $487,862 award, effective September 1, 2024 through May 31, 2029, will support three research aims: 1) determining the role of photoreceptor adaptation in shaping retinal ganglion cell (RGC) responses, 2) probing the contribution of RGC...
This $477,109.00 Project Grant award from the National Eye Institute (NEI) under the NIH's Vision Research grant program (CFDA 93.867) supports research at the University of Texas Southwestern Medical Center to investigate how the PRDM13 transcriptional regulator controls retinal cell fate determination and photoreceptor development. The goal is to better understand the molecular mechanisms underlying retinal degeneration, with the potential to inform future clinical therapies for preserving...
The National Eye Institute (NEI) awarded a $240,000 Project Grant (CFDA 93.867 - Vision Research) to Baylor College of Medicine to conduct research focused on "Characterization of the Nascent Retinal Proteome Regulating Hippo Signaling During Damage." The project aims to use cell type-specific metabolic labeling and purification techniques to identify the immediate molecular regulators of the Hippo signaling pathway in muller glial cells of the damaged mouse retina. This information is...
This $1,789,542.00 federal Project Grant awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to identify and characterize the regulatory mechanisms controlling the expression of key early retinal transcription factor genes during development in the murine and human retina. The research team at St. Jude Children's Research Hospital, the grant recipient, will test the hypothesis that the SIX3/SIX3 and OTX2/OTX2 genes are regulated by...
The National Eye Institute (NEI) awarded a $624,230 Project Grant (CFDA 93.867 - Vision Research) to the University of California, Los Angeles (UCLA) with a performance period from May 1, 2025 to April 30, 2029. The grant supports research to investigate the physiology and adaptive mechanisms of the degenerating retina, focusing on understanding how rod photoreceptors and their connections to bipolar cells are affected as retinal degeneration progresses. Key objectives include documenting...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) to The Washington University in St. Louis provides $480,376 to support research on the regulation of retinal development by RNA molecules. The project aims to investigate the role of long non-coding RNAs (lncRNAs) in controlling retinal gene regulatory networks, including through interactions with transcription factors. Key research activities include utilizing gain-of-function and loss-of-function...
This $606,034 Project Grant awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) supports research to investigate the role of Müller glia cells in the acute and chronic inflammatory response in the retina under various stress, injury, and disease conditions. The research aims to provide a deeper understanding of the molecular and cellular mechanisms that maintain retinal homeostasis and how those mechanisms are disrupted during acute and...
The National Eye Institute (NEI) awarded a $147,486 Project Grant under the NEI Vision Research federal grant program (CFDA 93.867) to The Johns Hopkins University. The award, effective June 1, 2025 through May 31, 2030, will fund research to evaluate the regenerative potential of human retinal ganglion cells (RGCs) and their ability to restore optic nerve function and visual recovery. The research aims to systematically investigate how modulating intrinsic factors in RGCs can promote optic...