This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will provide $477,109 over 5 years (May 1, 2025 - Apr 30, 2030) to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on gene regulation and cell fate determination in retinal development. The research aims to determine how the transcriptional regulator PRDM13 influences the formation of photoreceptors, which are critical for vision...
This is a Project Grant award from the National Eye Institute (NEI), part of the National Institutes of Health (NIH), under the Vision Research program (CFDA 93.867). The $451,000 award supports research by the University of Texas Southwestern Medical Center to investigate the role of the FIC enzyme in regulating the unfolded protein response (UPR) in the mammalian retina. Specifically, the project aims to determine if FIC-mediated modification of the BIP protein can modulate UPR activation,...
This federal Project Grant award of $237,588.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to understand the neural mechanisms underlying sensory encoding and visual behaviors after photoreceptor degeneration. The project aims to characterize the impact of cone loss on noise correlations in motion-sensitive retinal ganglion cells and how this affects the optokinetic reflex, a visual behavior that tracks global motion. The research will leverage the cone-DTR...
This Project Grant award from the National Eye Institute (NEI), under the CFDA 93.867 Vision Research program, will support research to investigate changes in rod photoreceptor function and retinal plasticity during the progression of retinal degeneration. The $624,230 award, effective from May 1, 2025 to April 30, 2029, will be conducted by researchers at the University of California, Los Angeles (UCLA). The key objectives of the project are to: 1) Document changes in rod membrane potential,...
The federal Project Grant award from the National Eye Institute (NEI), under the NEI Vision Research federal grant program (CFDA 93.867), provides $116,888 to The Regents of the University of California, San Francisco (UCSF) to study how mechanosensitive channels affect the light response of perivascular retinal ganglion cells (RGCs). The project aims to uncover novel neurovascular protective mechanisms against degeneration and explore new strategies for intervention in retinal diseases. The...
This National Eye Institute (NEI) Project Grant award under the Vision Research federal grant program (CFDA 93.867) in the amount of $121,665 supports research to investigate the effects of regional neural architecture on signal processing in the macaque retina. The key objectives are to: Examine single cell metrics of rod pathway sensitivity across different retinal regions to bridge the gap between mechanistic understanding of rod pathway sensitivity and regional sensitivity indicated by...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports research focused on identifying cellular mechanisms and therapeutic targets for retinopathies caused by ischemia or trauma, including diabetic retinopathy, retinal artery or vein occlusion, and traumatic optic neuropathy. The central hypothesis is that upregulation of the enzyme histone deacetylase 3 (HDAC3) in myeloid cells after retinal injury increases...
This federal Project Grant award of $410,000.00 from the National Eye Institute (CFDA 93.867 - Vision Research) to the University of Texas Southwestern Medical Center supports research to understand the molecular mechanisms by which the Wnt signaling pathway, including the Norrin ligand and its co-receptors, contribute to the development and maintenance of the blood-retina barrier and blood-brain barrier. The award will leverage biochemical and biophysical approaches using recombinant receptor...
This Project Grant award, valued at $125,916.00 and provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research to investigate the transcriptional and developmental basis of a human X-linked homeotic hotspot. The project aims to characterize the genetic landscape and expression patterns associated with a rare case of bilateral anophthalmia (missing eye globes) and XX sex reversal syndrome caused by a de novo mutation on the long arm of the...
The National Eye Institute (NEI) awarded a $414,711 Project Grant (CFDA 93.867 - Vision Research) to Albert Einstein College of Medicine to establish and utilize a microphysiological system for elucidating the mechanisms underlying early optic disc and stalk development, retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding in human development and the pathogenesis of blinding retinal diseases. The project aims to 1) dissect the mechanisms underlying the specification and...