Project Grant R01EY035855
Award Date
9/30/24
Completion Date
4/30/28
Dollars Obligated
$1.3M
Federal Agency
National Eye Institute
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Oklahoma City, OK 73104, USA
Similar Awards
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $247,700 to the University of Utah to establish a chimeric mouse model to study human retinal microglia in vivo. The key objectives are to: Characterize the engraftment and distribution of human xenotransplanted microglia in the mouse retina and optic nerve, and assess the impact on host retinal cells and tissue organization. Use single-cell RNA sequencing to define the transcriptome of the human...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $475,442 to the University of California, Los Angeles (UCLA) to conduct research focused on understanding the mechanisms underlying the ingestion of photoreceptor outer segment tips by the retinal pigment epithelium (RPE). The research aims to investigate the dynamic actin polymerization and trogocytosis process involved in this essential cellular function, as well as the daily timing of outer...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to investigate the role of myeloid cells in axon damage and degeneration associated with glaucoma. The research aims to determine whether NAD+-boosting interventions, which have shown promise in promoting axon protection, work through an anti-inflammatory mechanism by inhibiting myeloid cell recruitment. The award provides $423,767.00 over a 2-year period...
This $421,600 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) will support research at Tufts Medical Center in Boston, MA to investigate the regulatory mechanisms governing retinal neovascularization. The research aims to delineate the role of chemokine signaling in recruiting peripheral immune cells to facilitate pathological vascular growth, as well as the role of microglial complement receptors in regulating neovessel regression. The project will utilize...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to investigate the role of Müller glia in the retinal inflammatory response to stress, injury, and disease. The $606,034 award to St. Jude Children's Research Hospital Inc. will fund a 5-year study to profile the acute and chronic inflammatory pathways in the retina across various disease models, with a focus on the coordinating function of Müller glia. The research aims to...
This $439,137 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) to the University of Arkansas for Medical Sciences (UAMS) to support research aimed at identifying cellular mechanisms and therapeutic targets for retinal neurovascular diseases such as diabetic retinopathy, retinal artery/vein occlusion, and traumatic optic neuropathy. The research will focus on studying the process of "efferocytosis", which refers to the...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $253,500.00 to the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The research aims to optimize an in vitro outer blood-retina barrier model, generate isogenic models with different APOE...
This Project Grant award of $2,305,702 from the National Eye Institute (CFDA 93.867 Vision Research) aims to conduct integrative multi-omics research to discover molecular pathways associated with diabetic retinopathy (DR). The key products and services to be delivered include: Quantifying differential transcript and metabolite abundance between participants with type 2 diabetes with and without clinical DR diagnosis in the Cameron County Hispanic Cohort and replicating findings in the...
This Project Grant award of $1,593,473.00, provided by the National Eye Institute under the Vision Research program (CFDA 93.867), will support a multiomic analysis of preclinical biomarkers for primary open-angle glaucoma (POAG). The study aims to analyze proteomic and metabolomic markers, and their interactions with genetic predisposition, to advance understanding of POAG pathophysiology. Researchers will use plasma samples from a nested case-control group within ongoing prospective cohorts,...