This $168,396 Project Grant award from the National Eye Institute (NEI), under the CFDA 93.867 Vision Research program, supports research to elucidate the cellular and molecular mechanisms underlying the pro-regenerative effects of a conditioning lens injury on retinal ganglion cells (RGCs) following optic nerve crush injury. The award recipient, the Regents of the University of Michigan, will conduct two specific aims: 1) investigate the role of α-crystallins in RGC protection and axon...
This federal Project Grant award for $624,230, provided by the National Eye Institute (NEI) under its Vision Research program (CFDA 93.867), supports research to investigate changes in rod photoreceptor function and retinal remodeling in models of retinal degeneration. The primary objectives are to: 1) document alterations in rod membrane properties, light responses, and connections to bipolar cells as degeneration progresses, and 2) explore the plasticity of photoreceptor signal propagation and...
This $429,016 federal Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) to Oakland University supports research to identify the mechanisms by which a subset of retinal amacrine cells, called starburst amacrine cells, initiate and propagate spontaneous cholinergic waves in the developing retina. The objectives are to determine the distribution and properties of these cholinergic wave "pacemaker" cells (Aim 1) and to elucidate the calcium-dependent...
The National Eye Institute (NEI) awarded a $1,765,704 Project Grant (CFDA 93.867 - Vision Research) to Trustees of Boston University to develop an injectable, high-precision optoacoustic retina prosthesis for minimally invasive stimulation of the retina. The key products and services to be delivered under this 3-year project include: Development of a highly efficient photoacoustic injectable biomaterial for retinal stimulation Demonstration of micrometer-scale (40-50 μm) resolution retinal...
This Project Grant award from the National Eye Institute (NEI), under the NEI Vision Research federal grant program (CFDA 93.867), will support research aimed at developing therapies to regenerate optic nerve connections and restore vision. The key objectives are to: 1) Evaluate the long-term functional recovery and integration of neural stem cell-derived neuronal relays in the injured optic nerve, 2) Investigate the role of developmental guidance cues in directing the growth of neuronal relay...
The National Eye Institute (NEI) awarded a $606,025 Project Grant (CFDA 93.867 Vision Research) to William Marsh Rice University to develop a high-resolution visual prosthesis using large-scale, ultraflexible electrodes to interface with the lateral geniculate nucleus (LGN) and restore visual function in blind individuals. The project aims to establish the feasibility and acquire key knowledge to build a lasting LGN visual prosthesis with unprecedented visual field coverage able to elicit...
This R21 grant award, valued at $232,500, was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to The Johns Hopkins University. The project aims to test the use of patterned micro-stimulation of the visual cortex as a prosthetic strategy for restoring 3D object vision. Specifically, the researchers will investigate whether micro-stimulation of neurons in the ventral visual pathway that encode 3D geometric fragments can evoke the...
This $475,000 Project Grant awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) will support research to characterize the neural circuits and information processing in the visual system of mice. The key objectives are to: Identify the specific pathways in the dorsal lateral geniculate nucleus (dLGN) of the thalamus that transmit different types of visual information (motion-tuned vs. non-motion-tuned) from the retina to the primary visual cortex (V1)....
The National Eye Institute (NEI) awarded a $227,265 Project Grant (CFDA 93.867 Vision Research) to the University of California, Berkeley to map human retinal ganglion cell receptive fields and connect light stimulation of individual retinal photoreceptors to retinal ganglion cell activity and visual perception. The primary objectives are to: 1) leverage adaptive optics-stabilized microstimulation of the photoreceptor mosaic to precisely control input to the retina and disentangle the perceptual...
The National Eye Institute (NEI) awarded a $487,862 Project Grant under the Vision Research program (CFDA 93.867) to the University of Washington. The grant, with a period of performance from September 1, 2024 to May 31, 2029, will support research to understand how the retina adapts to dynamic changes in light intensity encountered in natural environments. The overarching goal is to investigate how diverse retinal adaptation mechanisms work together to provide reliable visual signaling to the...