Project Grant R01ES038104
- Federal Grant Award Summary Florida International University received a $489,258 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded April 24, 2026, with completion targeted for March 31, 2031. This research project investigates the crosstalk between epitranscriptomic RNA modifications, specifically N6-methyladenosine (m6A), and DNA damage repair mechanisms in response to environmental genotoxic...
- Federal Project Grant Award Summary Michigan State University's Health Sciences partnership (in collaboration with Henry Ford Health) received a $1.58M Project Grant from the National Institute of Environmental Health Sciences (NIEHS) Environmental Health program (CFDA 93.113), awarded April 1, 2026, with completion targeted for January 31, 2031. The research investigates the epigenetic control mechanisms of high-confidence autism spectrum disorder (ASD) genes, with particular emphasis on the...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded a $157,500 Project Grant to the Regents of the University of California at Riverside on July 9, 2025, under the Environmental Health program (CFDA 93.113). This two-year award (completion date: July 8, 2027) funds pilot research investigating gene-environment interactions in autism spectrum disorder (ASD) risk through developmental exposure to per- and polyfluoroalkyl substances (PFAS), commonly...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded a $498,000 Project Grant (CFDA 93.113 – Environmental Health program) to Icahn School of Medicine at Mount Sinai on August 25, 2025, with completion expected by July 31, 2028. This R00 Career Transition Award supports research investigating how prenatal exposure to fine particulate air pollution (PM2.5) influences neurodevelopmental outcomes in children. The investigator will leverage existing...
- Federal Grant Award Summary North Carolina State University received a $361,849 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective June 1, 2026, through March 31, 2031. The award supports research investigating mast cells as a key mechanistic link between developmental exposure to environmental toxicants—specifically the flame retardant Firemaster 550 (FM550)—and increased neurodevelopmental risk,...
- Federal Project Grant Award Summary Florida Institute of Technology Inc. received a $439,974 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded June 15, 2026, with a completion date of May 31, 2029. The research project, "Identifying the Genetic Determinants of Insecticide Response Variation to Advance Human Risk Assessment," delivers integrated quantitative genetics and human cell culture...
- Federal Project Grant Award Summary Drexel University received a $111,199 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded April 3, 2026, with completion by March 31, 2028. This career development award (K99/R00 mechanism) supports research investigating the role of phthalates and phenols—endocrine-disrupting chemicals found in consumer products—on phenotypic variability in autism and co-occurring...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded a K99/R00 career development grant of $241,326 to the University of California, Los Angeles (UCLA) on September 4, 2025, through the Environmental Health program (CFDA 93.113). This award supports a two-year research project extending through August 31, 2027, led by Dr. O'Sharkey to investigate the relationship between air pollution (AP) sources and autism spectrum disorder (ASD) risk...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded The Research Foundation For The State University of New York (RF-SUNY at the University at Albany) a $814,154 Project Grant under the Environmental Health program (CFDA 93.113) beginning April 1, 2026, with a completion date of March 31, 2031. This five-year award supports research investigating the interplay between the epitranscriptome and epigenome in regulating cellular responses to...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $649,193 Project Grant from the National Institute of Environmental Health Sciences under the Environmental Health program (CFDA 93.113), effective April 1, 2026 through March 31, 2031. This award supports mechanistic research investigating how naturally occurring toxic heavy metals—specifically arsenic, cadmium, chromium, and nickel—disrupt epitranscriptomic regulation and induce pathogenesis in...
Grant Award Summary Florida International University received a $772,659 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective July 1, 2026 through June 30, 2031. The award funds a comprehensive research investigation examining epitranscriptomic modifications—specifically N6-methyladenosine (m6A) and related RNA modifications—and their relationship to autism spectrum disorder (ASD) pathogenesis in relation to prenatal environmental exposures and protective factors. The research project delivers multiple integrated research products, including epidemiological analysis of maternal exposure data and biospecimen analysis from the MARBLES and EARLI cohorts, generation and characterization of brain organoid models derived from induced pluripotent stem cells (iPSCs), multi-omics molecular analysis employing RNA-sequencing, DNA methylation assays, and MeRIP-sequencing methodologies, and development of machine learning-based predictive models for ASD risk assessment and severity stratification. The research initiative addresses critical knowledge gaps regarding the mechanisms by which environmental toxicants (such as cadmium and per- and polyfluoroalkyl substances) and protective factors (such as folic acid) disrupt neurodevelopment through epitranscriptomic pathways. Deliverables include identification of exposure-specific epitranscriptomic signatures, characterization of sex-specific RNA modification patterns associated with ASD phenotypes, assessment of organoid-based models demonstrating exposure impacts on neurodevelopment, and development of non-invasive screening tools and targeted intervention strategies based on disrupted epitranscriptomic crosstalk mechanisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $772.7k | 6/19/26 |