This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $462,500.00 to St. Jude Children's Research Hospital Inc. to decipher the genetic regulation of bacterial heterogeneity in response to antibiotic stress using single-cell transcriptomics.
The research aims to comprehensively characterize bacterial heterogeneity and identify underlying genetic regulators that could...
The National Science Foundation (NSF) awarded a $1,500,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Alabama at Birmingham (UAB) to study the spread of antibiotic resistance genes in microbial communities. The research will investigate how heavy metal pollution affects the horizontal gene transfer of antimicrobial resistance genes within the environment, particularly in a historically contaminated area of Birmingham, Alabama. The project aims to...
This $495,166 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a research project at Fordham University titled "Molecular Mechanisms of Y-Family Translesion Polymerase Activity in Bacillus subtilis". The project aims to provide a comprehensive picture of the spatial organization, dynamics, and molecular coordination of the translesion DNA synthesis polymerases Pol Y1...
This National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program Project Grant award of $463,157 to the University of California, Berkeley will support research to unravel the interplay between self-organization and antimicrobial resistance (AMR) evolution across spatial scales. The objectives are to measure and model how AMR evolution depends on the self-organization of bacterial populations, ranging from micro-scale biofilms to gut-lumen...
This Project Grant award of $1,534,925.00 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Baylor College of Medicine to uncover the specific genes and molecular mechanisms that enable bacterial adaptations and the development of antibiotic resistance. The study aims to apply principles of statistical mechanics and thermodynamics to analyze mutational patterns in E. coli and identify the key genes conferring antibiotic resistance. By...
This $368,774 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate how nutrient availability in the host environment regulates the physiology and antibiotic resistance of Gram-positive anaerobic cocci (GPAC) bacteria. The project aims to determine how specific nutrient cues drive GPAC to adopt recalcitrant growth states like slow growth and biofilm...
The federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $241,500.00 to New York University to develop a high-throughput screening approach to discover protein-based efflux pump inhibitors (EPIs) that can block antibiotic resistance in pathogenic bacteria. The goal is to establish a robust assay that can efficiently identify EPIs without requiring extensive sample optimization, thereby...
This $483,990.00 five-year Project Grant award, titled "EVOLUTIONARY TRADEOFFS IN ANTIBIOTIC RESISTANCE", was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award recipient, the President and Fellows of Harvard College, will conduct laboratory studies exploring evolutionary tradeoffs related to antibiotic resistance in bacteria. The research aims to expand the understanding of...
This $456,746 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support research at The Pennsylvania State University (Penn State) aimed at understanding how insertion sequence (IS) elements in bacterial genomes can generate heterogeneous subpopulations through chromosomal amplification.
The research will focus on using the IS1 element in Escherichia coli B as a model system to: 1) explore...
This Project Grant award, valued at $195,625 and provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research program), supports research at the University of Colorado Boulder to structurally and functionally characterize the phosphoethanolamine transferase (PETn) enzyme. PETn is responsible for conferring polymyxin/colistin resistance in certain deadly, multidrug-resistant Gram-negative bacteria such as Acinetobacter baumannii,...