This $776,150.33 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to examine the relationships between exposure to the antimicrobial and endocrine disrupting compound triclosan, pubertal hormones, the adolescent gut microbiome, and neurobehavior. The primary awardee, the University of Massachusetts, will leverage a longitudinal birth cohort study to profile the adolescent gut...
The University of California, Davis has been awarded a $423,657 Project Grant (CFDA 93.113 - Environmental Health) from the National Institute of Environmental Health Sciences (NIEHS) to study the impact of neonatal exposure to per- and polyfluoroalkyl substances (PFAS) on the microbiota-gut-brain axis. The research aims to determine if neonatal PFOA exposure leads to long-term deficits in the microbiota-gut-brain axis, including impacts on gut physiology and behavior, as well as whether...
This $2,166,750 project grant from the National Institutes of Health's National Institute of Environmental Health Sciences will fund research into the role of the gut microbiome in host adaptation to environmental xenobiotics. The University of California, Berkeley will explore how exposure to commonly used pesticides shapes the gut microbiome of the model organism C. elegans, and the long-term health consequences for the host. Researchers will characterize microbiome-assisted adaptation to...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $794,841 Project Grant (CFDA 93.113 - Environmental Health) to the University of California, San Diego (UCSD) to investigate the effects of early-life triclosan exposure through lactation on the gut-liver axis and its implications for the development of metabolic dysfunction-associated steatotic liver disease (MASLD) in adults. The research aims to elucidate the mechanisms by which lactational triclosan exposure...
This Project Grant award of $510,412.27 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund research to investigate the role of the gut microbiota in alcohol seeking and reward-related decision-making. The research will use mouse models and computational modeling to determine if manipulating the gut microbiota, such as through the use of prebiotics, can mitigate alcohol-induced behavioral impairments. The award period...
This federal Project Grant award of $728,029.00 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to understand the role of gut microbiota, inflammation, and metabolomics in heat-related illness (HRI). The overarching goal is to assess how gut microbial communities, systemic and gut inflammation, short-chain fatty acids, and primary/secondary bile acids influence the likelihood and severity of HRI. The...
This federal Project Grant award of $125,809 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how non-antibiotic prescription medications impact the gut microbiome and affect the risk of gastrointestinal infections. The award recipient, Yale University, will establish mouse models to study how specific drugs, such as the cardiac medication digoxin and the...
This Project Grant award of $222,750 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, will support research on the role of the Fc fragment of IgG binding protein (FcGBP) in the intestinal mucus layer and its impact on gut microbiota composition. The primary goals are to determine how FcGBP contributes to the glycosylation and sialylation of the colon mucus layer, and how this affects the abundance of specific...
This $926,057 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research is supporting research to understand how the gut microbiota influences immune responses, particularly B-cell development and antibody production, following vaccination. The project aims to identify gut stromal cell populations and microbial components that are crucial for enhancing stromal cell function and promoting improved...
This federal Project Grant award of $372,500.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Wisconsin-Parkside to characterize the enzymatic activities and metabolic functions of key gut bacteria in the Bacteroides genus. The research aims to provide clarity on fatty acid metabolism and coenzyme A availability within these bacteria, which have important implications for...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $1,946,073 to the University of Washington to conduct research on the impact of benzalkonium chloride (BAC) exposure on the gut microbiome and gut-liver interactions.
The key objectives of this 5-year project are to: 1) characterize the effect of BAC exposure on gut microbiome composition, function, and metabolism, and correlate changes with gut bile acid, sterol, and lipid profiles; 2) measure the effect of BAC exposure on bile acid, sterol, lipid, and xenobiotic metabolism in the liver of conventional and germ-free mice, and assess nuclear receptor activation/inhibition; and 3) evaluate the relationship between BAC levels and gut microbiome diversity and function in humans. This research aims to understand the impact of increased BAC exposure, which has risen significantly during the COVID-19 pandemic, on the gut-liver axis.