Project Grant R01ES024165

This three-year, $4.84 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at The Johns Hopkins University to investigate the neurological effects and cumulative risk of neurodegenerative disease from exposure to metal mixtures. Specifically, the researchers will examine the biological mechanisms by which exposure to mixtures of lead, arsenic, cadmium, and chromium during adulthood and early development cause...

This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $240,972 to the Regents of the University of Michigan to investigate the impact of metals exposure on dementia and related health outcomes. The project will leverage data from the National Alzheimer's Coordinating Center and the National Centralized Repository for Alzheimer's Disease and Related Dementias to examine the associations of metal concentrations with dementia prevalence, incidence,...

This Cooperative Agreement award, funded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), provides $2,175,074 to support a research project investigating the role of mid-life environmental toxicant exposures on the risk of Alzheimer's disease (AD) and AD-related dementias (ADRD). The project, led by the University of Pennsylvania, will leverage the ongoing Coronary Artery Risk Development in Young Adults (CARDIA) study to repeatedly measure...

The National Institute on Aging (NIA) awarded a 5-year, $2,533,483 Cooperative Agreement (CFDA 93.866 - Aging Research) to Columbia University to prospectively examine the relationship between environmental toxicants and the risk of Alzheimer's disease (AD) and AD-related dementias (ADRD). The project will leverage the existing Diabetes Prevention Program Outcomes Study (DPPOS) AD/ADRD cohort to conduct longitudinal untargeted exposomics, metabolomics, and measurements of metals, polyfluoroalkyl...

This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $4,422,126 to the Regents of the University of Michigan to conduct a multi-year research project on the impact of toxic metal exposures (lead, cadmium, arsenic) on brain aging and Alzheimer's disease and related dementias (ADRD). The project will use genetically diverse mouse models to comprehensively characterize how genetic risk interacts with metal exposures to cause molecular,...

This U01 Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,122,961 to leverage novel mouse models to investigate the impact of toxic metal exposures on brain aging and Alzheimer's disease (AD) pathobiology. The multi-disciplinary project team, led by researchers from Boston University, The Jackson Laboratory, and Indiana University, will expose genetically modified mouse models carrying AD-related risk factors to lead, cadmium, and...

This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,499,382 in funding to Duke University to advance research on the role of chemical exposures in Alzheimer's disease (AD) and related dementias. The project aims to expand coverage of the chemical exposome in blood and brain, and link identified signatures to brain aging, incident dementia, and AD. Key activities include metabolomics and lipidomics analyses, integrating exposome data...

The National Institute on Aging (NIA) awarded a 5-year, $2,278,304 Cooperative Agreement (CFDA 93.866 - Aging Research) to Emory University to investigate the biological mechanisms by which exposures to fine particulate matter (PM2.5) air pollution contribute to the development of Alzheimer's disease and related dementias (ADRD). The project, titled "IMPACT-ADRD: Investigating the Multi-omics Perturbations Associated with Complex Environmental Toxicants and Their Contribution to Alzheimer's...

This federal Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $837,485 to the University of Massachusetts Medical School (UMass Medical) to examine the effect of cadmium metal exposure on Alzheimer's disease genetic alleles using herpes viral infected cerebral organoids. The project aims to: 1) Perform RNA-sequencing to test for Alzheimer's-specific transcriptomic perturbation signatures upon cadmium exposure, with or without herpes simplex...

This $4,260,300 project grant from the National Institutes of Health's National Institute on Aging will fund research under the Aging Research program (CFDA 93.866) to investigate the association between in utero environmental exposures and life-course cognition and prodromal Alzheimer's disease in midlife. The Public Health Institute will leverage existing data and biospecimens from the 50+ year follow up of the Child Health and Development Studies birth cohort to conduct targeted and...