Project Grant R01EB037569
- The National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) awarded a $401,115 Project Grant to Thomas Jefferson University's Sidney Kimmel Medical College to evaluate the use of contrast-enhanced ultrasound (CEUS) in assessing the response of hepatocellular carcinoma (HCC) to transarterial radioembolization (TARE) treatment. The project aims to assess both qualitative and quantitative CEUS as a tool for evaluating HCC treatment response to TARE, including investigating...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) totaling $423,399.00 aims to develop and validate new ultrasound hardware technologies for high-contrast, high-resolution microvascular imaging. The goal is to detect abnormalities in vascular morphology, which can serve as biomarkers for various diseases ranging from cancer to...
- This $395,695 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop novel multi-modal ultrasound imaging methods for non-invasive, real-time monitoring of tissue healing and early prognosis. The project will investigate new prognostic markers related to vascular and interstitial fluid transport mechanisms to assess...
- The National Cancer Institute (NCI) awarded Imcare Biotech, Inc. a $364,763 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate SERAVUE AI, a novel multi-analyte algorithmic assay for early detection of hepatocellular carcinoma (HCC), the most common type of primary liver cancer. The project aims to create a highly accurate, non-invasive blood test for HCC surveillance that could potentially replace ultrasound as the standard screening...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $275,092 to the University of Wisconsin System to develop an accurate and robust targeting technique to enable transcostal histotripsy treatment of liver tumors. The project aims to improve histotripsy treatments for liver cancer by quantifying the effect of intervening ribs on targeting accuracy and developing a machine learning-based solution to overcome acoustic aberrations from the...
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) totaling $2,876,456 will support the development of a strategy for hepatocellular carcinoma (HCC) risk assessment in cirrhosis and non-cirrhosis patients with major viral and metabolic etiologies, as well as resources for cholangiocarcinoma (CCA) risk biomarkers. The grant will be used by the University of Texas Southwestern Medical Center to build upon their previously developed...
- The University of Pennsylvania received a $446,875 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award will support research to develop deep learning tools that can predict patient risk, generate synthetic clinical biomarkers, and provide normative data from multimodal and longitudinal health data related to metabolic...
- The University of Michigan has been awarded a $568,151 Project Grant from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to develop a real-time functional imaging platform for accurate diagnosis and prognosis of prostate cancer. The project aims to leverage photoacoustic imaging and biocompatible hydrogel nanoparticle probes to quantitatively assess prostate gland microarchitecture and tumor microenvironment as imaging biomarkers for improved prostate...
- This $726,205 federal Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports the development and validation of a new super-resolution intravascular ultrasound (SR-IVUS) technology. The goal is to enable effective imaging of the coronary vasa vasorum network and thin fibrous cap of vulnerable atherosclerotic plaques to better assess plaque vulnerability and prevent acute coronary syndromes. The project involves creating an...
- This Project Grant award of $306,739.00, provided by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), aims to improve treatment outcomes for patients with hepatocellular carcinoma (HCC), the most prevalent form of liver cancer. The research focuses on identifying the most effective inhibitors of the enzyme ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) in HCC models. ENPP1 plays a key role in suppressing the immune response against HCC...
This Project Grant award, provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286), supports research to develop a novel imaging method called "Hydralazine-Augmented Contrast Ultrasound (HYCUS)" for early-stage detection of hepatocellular carcinoma (HCC). The $499,909 award, granted on August 11, 2025, will be used by the University of Pennsylvania to validate the HYCUS technique in an autochthonous rat model of HCC with liver fibrosis. The project aims to establish HYCUS as a method for enhancing HCC visibility, develop an optimal imaging regimen, and evaluate the technique's effectiveness compared to standard ultrasound and alpha-fetoprotein testing. The research seeks to advance early-stage HCC detection capabilities, which could significantly improve survival rates for this leading cause of cancer-related deaths.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $499.9k | 8/11/25 |