Project Grant R21EB036670
- This federal Project Grant award, valued at $375,337.00 and provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of photothermal mid-infrared single molecule super-localization microscopy to track the intracellular processes governing mRNA release from lipid nanoparticle (LNP) formulations. The goal is to provide...
- This federal Project Grant award of $374,095 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a device that uses an infrared laser to enable local delivery of a high dose of chemotherapy to the surgical cavity after tumor resection. The technology employs thermosensitive liposomal nanoparticles encapsulating chemotherapy agents that...
- This federal Project Grant award from the Department of Defense's Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $3,984,239.00 to Microvascular Therapeutics Inc. to conduct IND-enabling studies for targeted phase shift microbubbles for sonothrombolysis. The funding supports research and development activities by the for-profit biotechnology company to advance ultrasound contrast agent and delivery system technologies for diagnostic and...
- This $516,762 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports fundamental research at the University of Central Florida (UCF) to develop a new ultrasonic shearing method for scalable manufacturing of uniform-sized nanobubbles. The research aims to advance nanobubble production capabilities, particularly for biomedical applications like drug delivery and medical imaging. Key aspects include computational modeling of the ultrasonic...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $306,463 Project Grant under the CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health" program to Dogpatch Medical LLC, effective September 1, 2025 through August 31, 2026. The grant funding supports the development of PASSIVECATH, an innovative microcatheter device designed for enhanced visibility and targeted drug delivery to the central nervous system...
- This $395,695 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop novel multi-modal ultrasound imaging methods for non-invasive, real-time monitoring of tissue healing and early prognosis. The project will investigate new prognostic markers related to vascular and interstitial fluid transport mechanisms to assess...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $263,749 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Sound Innovation LLC in Albany, NY. The grant supports the development of a portable small animal imager to accelerate drug development. The project aims to create a cost-effective and high-quality imaging solution to improve the preclinical stage of the drug development...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $304,196 to Laser Bioanalytics LLC for the development of a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable improved mass spectrometry structural analysis and imaging of lipids, which are important cellular components relevant to disease diagnosis...
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of extracellular vesicles (EVs) as therapeutic carriers. The $622,000 award, effective August 1, 2024 through July 31, 2027, will enable researchers at The Washington University in St. Louis to engineer endothelial cell-derived EVs to efficiently...
- This $342,776 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop advanced data science methods and an automated pipeline for efficient and high-performance monoclonal antibody (mAb) formulation. The goals are to create a self-driving bioformulation laboratory that leverages artificial intelligence, machine...
This federal Project Grant award, valued at $630,000.00, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant aims to develop a novel "light-activated site-specific conjugation (LASIC)" technology to improve the manufacturing and performance of targeted microbubble theranostic agents for clinical applications. Specifically, the project will: 1) Create targeted microbubbles using LASIC to attach antibodies, 2) Generate theranostic microbubbles by using LASIC to attach therapeutic payloads, and 3) Evaluate the biodistribution of the LASIC-optimized microbubbles via image-guided catheter delivery in an oncopig liver tumor model. Successful completion of this 3-year project (9/1/2025 - 8/31/2028) is expected to facilitate the clinical translation of this innovative microbubble theranostic technology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $630.0k | 8/6/25 |