This federal Project Grant award, valued at $882,000.00, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award, effective May 1, 2025 through April 30, 2028, supports research to engineer natural killer cell-derived extracellular vesicular nanoparticles as a targeted drug delivery system for cancer imaging and therapy. Key objectives...
This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $375,134 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, for a 5-year research project starting March 1, 2025. The project aims to investigate a novel approach to reduce the accumulation of chemotherapeutic nanomedicines in healthy tissues, thereby improving the efficacy and reducing the toxicity of cancer treatments. The...
This $536,836 Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) supports research to develop mathematical models and computational methods for optimizing the delivery of a transarterial ablative therapy for treating hepatocellular carcinoma (liver cancer). The key products and services to be delivered under this grant include: Formulating mathematical models that describe multi-constituent, chemically reacting fluid flow and heat...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $519,210 Project Grant (CFDA 93.286: Discovery and Applied Research for Technological Innovations to Improve Human Health) to the Regents of the University of Michigan. This grant will fund research to develop nanoparticle strategies for reprogramming innate immune cells, such as monocytes and neutrophils, to disrupt the metastatic niche and enhance anti-tumor immune responses in triple negative breast cancer....
This Project Grant award of $427,095 from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) will support the development of a novel microfluidic droplet-based platform (MDP) technology at Northeastern University. The goal is to generate and analyze a 3D biomimetic multicellular immunogenic tumor model that can: Establish multiple levels of hypoxia within a tumor-on-a-chip for parallel processing. Investigate the spatiotemporal interaction...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $374,095 Project Grant (CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health") to Oncoblaze LLC in Charleston, SC. The purpose of this grant is to develop a device that uses an infrared laser to expose surgical cavities to optimal temperatures for the release of chemotherapy from thermosensitive liposomal nanoparticles (TNP). This technology aims to enable...
This National Science Foundation Project Grant of $255,995 supported Encapsulate Inc. to develop an automated biochip platform for personalized cancer screening under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The award period was from May 15, 2022 to April 30, 2023. The platform will grow patient-derived cancer cells outside the body on biochips to screen them against chemotherapy drugs. This addresses the problem that over 70% of cancer patients undergo ineffective...
This Project Grant award R01HL171715, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a non-invasive imaging strategy for quantifying chemotherapy-induced vascular toxicity. The $583,381 grant will support research to validate 18F-FDG PET/CT imaging as a biomarker for detecting chemotherapy-induced venous toxicity, evaluate its prognostic value for predicting venous thromboembolism (VTE) risk in...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $275,773 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Dropletpharm Inc., a for-profit company. The grant supports Dropletpharm's development of microfluidic technologies to enable low-cost and distributed manufacturing of radiopharmaceuticals for clinical and research applications. Specifically, the project aims to expand...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $416,796 project grant to the Colorado School of Mines under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program. This grant will fund research and development of aerosolized microbots for targeted drug delivery to lung cancer tumors. The key objectives are to: 1) identify magnetic field conditions for delivering the microbot swarm to specific...