Project Grant R01EB036030
Award Date
9/1/24
Completion Date
5/31/28
Dollars Obligated
$519K
Federal Agency
National Institute of Biomedical Imaging and Bioenginering
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
Michigan, USA
Similar Awards
The National Cancer Institute (NCI) awarded a $949,094 Project Grant under the Cancer Treatment Research (CFDA 93.395) program to the Regents of the University of Michigan. The grant will fund research aimed at targeting cancer stem-like cells in triple negative breast cancer (TNBC) by exploiting their overexpression of two redox regulating enzymes, NQO1 and SOD1. The project will evaluate the use of the NQO1-bioactivatable compound IB-DNQ, alone or in combination with SOD1 inhibition, to...
This Project Grant award of $1,302,368 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will establish a National Center for Biomedical Imaging and Bioengineering at the University of Michigan. The center will develop microsystems-based imaging technologies, including miniature scanners, actuators, and sensors for fiber-coupled microendoscopes to enable...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $882,000 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The University of Texas at Tyler. The grant aims to engineer hybrid extracellular vesicles (HEVs) derived from natural killer (NK) cells and liposomes containing the anticancer drug doxorubicin and a near-infrared dye for targeted cancer imaging and therapy. Specific...
This Project Grant award for $599,998 from the National Science Foundation's (NSF) Engineering Program (CFDA 47.041) supports research by the Regents of the University of Michigan to investigate how biomaterial surface topographies can modulate interactions between the host immune system and pathogens to enhance infection control for medical implants. The central goal is to elucidate how precisely engineered 2D and 3D topographical cues on biomaterials can restore immune balance and improve...
This federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) provides $427,095 to Northeastern University to develop a novel microfluidic droplet-based platform (MDP) technology. The MDP will generate and analyze a 3D biomimetic multicellular immunogenic tumor model to: Establish multiple levels of hypoxia within the same tumor-chip for parallel processing. Investigate spatiotemporal interaction between the...
This $1,628,163 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) supports research to develop a ferritin-degrading molecule (designated DEFER) that can degrade ferritin, a key regulator of iron levels in triple-negative breast cancer (TNBC) cells. The research aims to optimize DEFER, investigate its ferritin degradation mechanisms, and evaluate its in vitro...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $359,995 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to Clemson University. The funding supports the development and validation of a novel X-ray visualized immunosensor (X-VIS) that can be attached to implanted medical devices to detect and monitor local infection biomarkers. The project aims to fabricate a...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the CFDA 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health program, provides $1,091,260 over approximately 4 years from February 2025 to January 2029. The objective is to develop bispecific antibodies (bAbs) fused to interleukin-2 (IL-2), referred to as IL-2 immunocytokines, that can non-invasively and efficiently deliver IL-2 to the central...
This National Science Foundation Project Grant of $299,785 will fund research into the integrated effects of mechanical and biochemical factors on breast tumor invasion and metastasis. Awarded on September 1, 2022 under the Engineering program (CFDA 47.041), the grant supports a collaborative research project led by the University of Michigan from September 1, 2022 through August 31, 2025. Specifically, the research team will develop quantitative imaging biosensors and tissue-engineered breast...
This $732,000 Project Grant from the National Cancer Institute, part of the Department of Health and Human Services, will support research under the Cancer Treatment Research program. The grant recipient, Northwestern University, will develop a bridge-lipid nanoparticle platform to reprogram immunosuppressive tumor-associated myeloid cells and potentiate radiotherapy for glioblastoma. Over a five-year period, the university will conduct three aims: harnessing myeloid cells to phagocytose...