Project Grant R01DK149689
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Virginia $797,878 on February 24, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the pathogenesis of concentric hypertrophy of kidney arterioles. The research examines how chronic stimulation of renin cells—triggered by renin-angiotensin system inhibitors or genetic mutations—leads to concentric arterial and arteriolar hypertrophy, a...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $1,636,543 on March 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the ubiquitin editor A20 in regulating sodium transport and the hypertensive response through selective actions in kidney epithelial cells and tubules. The research addresses the mechanisms through which A20 suppresses inflammatory cytokines that modulate...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Virginia Commonwealth University $714,743 on August 13, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of PIEZO1 mechanosensitive ion channels in renal medullary telocytes as pressure sensors regulating blood pressure through exosome-mediated signaling. The research will elucidate mechanisms of pressure natriuresis—the process by which...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Florida $663,104 on February 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the clock protein PER1 in regulating blood pressure and kidney function in salt-sensitive hypertension. The research examines how PER1 suppresses aldosterone signaling through the mineralocorticoid receptor and endothelin-1 signaling in the kidney...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $821,916 on March 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms of angiotensin II signaling within kidney intercalated cells. The research examines how angiotensin II upregulates pendrin, a chloride-bicarbonate exchanger expressed on intercalated cells that modulates acid-base balance and blood pressure regulation. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $381,060 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project examines chronic stress as a risk factor for the development and progression of chronic kidney disease and identifies two physiological pathways linking stress to kidney disease: elevation of systemic inflammatory cytokines (IL-6 and CRP) and enhanced autonomic nervous...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Rush University Medical Center $749,087 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate sodium-independent mechanisms of edema in nephrotic syndrome. The project studies the role of circulating angiopoietin-like 4 (ANGPTL4), specifically its C-fragment, as a mediator of skin capillary endothelial permeability in nephrotic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Boston Medical Center Corporation $888,383 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate dietary potassium and gene-environment interactions in apolipoprotein L1 nephropathy. The research examines how dietary potassium intake modulates kidney disease progression and hypertension in individuals carrying APOL1 high-risk genotypes, which...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Massachusetts General Hospital $251,626 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on c-kit receptor signaling in kidney collecting duct function. The research investigates the role of c-kit receptor signaling in modulating collecting duct epithelial cell composition and function. The project uses c-kit "sash" mice...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Virginia $702,191 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic biomedical research on cell volume regulatory mechanisms and their role in autonomous aldosterone production. The research targets primary aldosteronism, a genetic condition characterized by excessive aldosterone production independent of the renin-angiotensin system and the most prevalent form of endocrine-related hypertension. The project investigates how cell volume regulators—specifically the sodium-potassium-chloride cotransporter 1 (NKCC1) and volume-regulated anion channel (VRAC)—modulate calcium oscillations in zona glomerulosa cells that initiate aldosterone synthesis. The work employs pharmacological and genetic manipulation of these regulators in mouse and human zona glomerulosa cells, both ex vivo and in vivo, combined with innovative imaging techniques and mouse models of primary aldosteronism to validate the hypothesis that cellular volume homeostasis machinery regulates aldosterone production independent of renin signaling. The project aims to identify osmotic and pharmacological pathways that attenuate aldosterone secretion without targeting renin, potentially establishing new therapeutic approaches for a condition that significantly elevates cardiovascular and stroke risk. Performance occurs in Charlottesville, Virginia, with a period of performance from September 1, 2026, through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $702.2k | 8/31/26 |