Federal Grant Award Summary

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Florida $663,104 through its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on February 2, 2026. This five-year project grant, extending through January 31, 2031, supports research investigating the renal and adrenal mechanisms of the circadian clock protein Period1 (PER1) in salt-sensitive hypertension. The research aims to advance understanding of how PER1 regulates blood pressure and kidney function, with particular focus on the downstream signaling pathways involving aldosterone and endothelin-1 that contribute to salt-sensitive hypertension and kidney disease.

The project will be conducted at the University of Florida's Division of Sponsored Research in Gainesville, Florida. The research deliverables include basic and translational biomedical investigations designed to elucidate the mechanisms by which PER1 suppresses pathways that promote hypertension and renal dysfunction, with the ultimate goal of identifying therapeutic targets for preventing or treating salt-sensitive hypertension and kidney disease. This award represents NIDDK's continued investment in extramural research addressing critical gaps in understanding disease mechanisms and developing improved interventions for diabetes, digestive, and kidney disease conditions.