Project Grant R01DK149540
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $148,155 on August 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support a five-year project examining the role of PIEZO1, a mechanosensitive cation channel, in renal function and fibrosis. The research investigates PIEZO1 regulation and activity in the distal nephron through two primary aims. Aim 1 examines how aldosterone and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Virginia $702,191 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic biomedical research on cell volume regulatory mechanisms and their role in autonomous aldosterone production. The research targets primary aldosteronism, a genetic condition characterized by excessive aldosterone production independent of the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Virginia $797,878 on February 24, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the pathogenesis of concentric hypertrophy of kidney arterioles. The research examines how chronic stimulation of renin cells—triggered by renin-angiotensin system inhibitors or genetic mutations—leads to concentric arterial and arteriolar hypertrophy, a...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $1,636,543 on March 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the ubiquitin editor A20 in regulating sodium transport and the hypertensive response through selective actions in kidney epithelial cells and tubules. The research addresses the mechanisms through which A20 suppresses inflammatory cytokines that modulate...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $821,916 on March 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms of angiotensin II signaling within kidney intercalated cells. The research examines how angiotensin II upregulates pendrin, a chloride-bicarbonate exchanger expressed on intercalated cells that modulates acid-base balance and blood pressure regulation. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $121,125 to the University of Virginia on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to engineer and optimize a three-dimensional microfluidic co-culture system that models the gut-on-chip and investigates how biomechanical forces—specifically stretch and stiffness—affect enteric neurons and glia. The project addresses chronic idiopathic constipation and...
- The National Institute of Diabetes and Digestive and Kidney Diseases, a component of the Department of Health and Human Services, awarded Virginia Commonwealth University $421,744 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the regulation of liver regeneration by hepatocyte-derived extracellular vesicles. The project will characterize the role of microRNAs carried by hepatocyte-derived extracellular vesicles...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beth Israel Deaconess Medical Center $1.552 million on September 9, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to map mechanosensory circuits from the bladder to Barrington's nucleus. The recipient will use immediate early gene activity, RNA sequencing, fiber photometry, and cellular-resolution calcium imaging to identify central nervous system nuclei and cell...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Rush University Medical Center $749,087 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate sodium-independent mechanisms of edema in nephrotic syndrome. The project studies the role of circulating angiopoietin-like 4 (ANGPTL4), specifically its C-fragment, as a mediator of skin capillary endothelial permeability in nephrotic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Arkansas for Medical Sciences $717,457 on February 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate metabolic rewiring of T cells and the pathogenic connection between diabetes and hypertension. The research examines immune-metabolic crosstalk in the progression from type 2 diabetes to hypertension using a high-fat diet-induced...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Virginia Commonwealth University $714,743 on August 13, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of PIEZO1 mechanosensitive ion channels in renal medullary telocytes as pressure sensors regulating blood pressure through exosome-mediated signaling. The research will elucidate mechanisms of pressure natriuresis—the process by which elevated renal perfusion pressure promotes sodium excretion and controls long-term arterial blood pressure. Telocytes are interstitial cells enriched in the renal medulla that express PIEZO1 and release exosomes. Preliminary data from a telocyte-specific PIEZO1 knockout mouse model demonstrate impaired natriuresis, reduced circulating exosome levels, and exacerbated salt-sensitive hypertension, supporting PIEZO1's functional role in blood pressure regulation. The project's specific aims include determining the role of renomedullary telocyte PIEZO1 channels in blood pressure regulation and salt-sensitive hypertension using knockout mice; characterizing mechanosensitive properties of PIEZO1 channels in telocytes by investigating the relationship between mechanical stimulation, PIEZO1 activation, calcium influx, and exosome release in cultured cells; and further elucidating the signaling pathways involved. Performance occurs in Richmond, Virginia. The award period runs through March 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $714.7k | 8/13/26 |