Project Grant R01DK146789
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Scripps Research Institute $142,600 on September 30, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to leverage in vivo protein tracking to identify novel immune markers associated with obesity-driven disease. The research develops and employs a Cre-inducible endogenous biotin-ligase BirA*G3 affinity tracking system expressed in mouse intestine to biotin-tag proteins...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Brandeis University $1.541631 million on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the molecular and circuit mechanisms of sensory functions in pharyngeal enteric neurons of the nematode C. elegans as a model system for understanding interoception—the process by which organisms sense and regulate internal signals to appropriately...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Scripps Research Institute $152,600 on February 15, 2027, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research examining how hepatic endoplasmic reticulum (ER) stress affects the integrity of the secreted proteome, with focus on protein aggregation diseases including systemic amyloidoses. The research will use established and novel proteomics...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beckman Research Institute of The City of Hope $280,232 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund research on gut-fat crosstalk in metabolic regulation. The award supports basic and translational research investigating intestinal mTOR signaling and its effects on white adipose tissue browning, glucose homeostasis, and energy metabolism....
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $782,886 on February 18, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support research on obesity control through an appetite-suppressing peptide. The research addresses the urgent need for new metabolies, including obesity and associated metabolic disorders. Work is performed in Palo Alto, California with a period of...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beth Israel Deaconess Medical Center $834,911 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK142743). The award funds research mapping selective brain-to-gut communication circuits that control gastrointestinal physiology from the distal esophagus to the proximal colon. The project will create a detailed roadmap of mammalian dorsal...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health under the Department of Health and Human Services, awarded $717,030 to the University of Virginia on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to uncover neural circuits controlling body weight and metabolism. The research develops and applies RAMPANT (rabies afferent mapping by poly-A nuclear transcriptomics), a novel...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Los Angeles $167,363 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support basic and clinical biomedical research on novel central nervous system mechanisms in obesity. The award funds research investigating how the paraventricular nucleus of the hypothalamus integrates nutrient-related cues to control peripheral energy and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded California Institute of Technology $661,126 on August 21, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Assistance Listing Project Grant R01DK149061). The award funds bacterial metatranscriptomics research aimed at resolving contributions of host and microbial pathways to human health and disease. Tissue-associated microbes play fundamental roles in shaping host...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Yale University $839,770 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support cognitive and behavioral approaches to reduce binge eating and excess weight in adolescents. The award is a Project Grant with a period of performance extending through February 28, 2031, and work is performed in New Haven, Connecticut. The program promotes extramural basic...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Scripps Research Institute $701,896 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate novel genetic pathways underlying brain-gut communication in C. elegans as a model for understanding systemic fat metabolism and metabolic dysfunction. The research systematically identifies and characterizes ciliated sensory neurons and the neuropeptide genome that modulate fat metabolism, with the goal of revealing new molecular targets for therapeutics addressing obesity and associated metabolic illnesses. The project hypothesizes that fat metabolism is controlled by distinct neural circuits utilizing neuropeptides that directly drive metabolic shifts in the intestine. Work is performed in La Jolla, California, with a period of performance running through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $701.9k | 8/14/26 |