Project Grant R01DK149061
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beckman Research Institute of The City of Hope $280,232 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund research on gut-fat crosstalk in metabolic regulation. The award supports basic and translational research investigating intestinal mTOR signaling and its effects on white adipose tissue browning, glucose homeostasis, and energy metabolism....
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $698,501 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify gene-level interactions between host immunity and the intestinal microbiota that regulate inflammation in inflammatory bowel disease. The funded research combines microbiota analysis tools, host single-cell RNA sequencing, and machine learning methods to...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Regents of the University of California, San Francisco $194,076 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds a multi-omic investigation of the gut-liver axis in HIV-related liver disease. The project will define mechanistic and biomarker pathways along the gut-liver axis that contribute to and predict hepatic fibrosis in people...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $100,228 on April 15, 2027, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research evaluates deterministic strain interactions and stochasticity in gut microbiomes using a specialized host-microbe model system pairing squash bugs (Anasa tristis) with their mutualistic gut bacterium (Caballeronia spp.). The project assesses how bacterial competition and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Davis $739,895 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate neonatal development of the microbiota-gut-brain axis. The research addresses how bacterial colonization of the gastrointestinal tract, formation of the GI mucosal barrier, and neurogenesis during early life establish a critical developmental...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Davis $180,109 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate restoration of microbiota signaling pathways using non-biotic substitutes—termed "faux-biotics"—to control opportunistic infections during chemotherapy-induced dysbiosis. The project addresses the loss of colonization resistance that occurs...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Scripps Research Institute $142,600 on September 30, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to leverage in vivo protein tracking to identify novel immune markers associated with obesity-driven disease. The research develops and employs a Cre-inducible endogenous biotin-ligase BirA*G3 affinity tracking system expressed in mouse intestine to biotin-tag proteins...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded President and Fellows of Harvard College $1,614,202 on July 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to decipher gut microbial metabolism of dietary polyphenols and its impacts on human health and disease. The research will identify and characterize gut microbial enzymes that metabolize multiple classes of polyphenols, elucidate the bioactivities and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas MD Anderson Cancer Center $151,136.00 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct multi-omic analyses of the gut microbiome and its relationship to metabolic dysfunction-associated steatotic liver disease (MASLD). The research integrates metagenomic, metabolomic, and metatranscriptomic analyses to explore microbial...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Boston Children's Hospital $831,433 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supporting research to redefine the biogeography and function of food proteins in human health and disease. The project establishes first principles of the food-host interactome by developing systematic approaches to map the transit, transformation, and tissue...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded California Institute of Technology $661,126 on August 21, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Assistance Listing Project Grant R01DK149061). The award funds bacterial metatranscriptomics research aimed at resolving contributions of host and microbial pathways to human health and disease. Tissue-associated microbes play fundamental roles in shaping host immunity, barrier integrity, and metabolism. The project examines gene-expression (RNA) level insights on microbes in human tissues to understand the functional significance of host-microbe interactions, addressing the challenge that bacterial RNAs are unstable and difficult to capture in tissue samples. Work is performed in Pasadena, California. The period of performance runs from the award date through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $661.1k | 8/20/26 |