Project Grant R01DK146260
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Medical College of Wisconsin $751,694 on April 21, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to optimize chronic tibial nerve stimulation (TNS) for treating neurogenic bladder dysfunction in individuals with spinal cord injury. The research investigates unanswered questions about TNS therapy dosing parameters, intervention timing, and long-term effectiveness...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $713,227 to the University of Wisconsin–Madison on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK146259). The award funds research on the role of A-fiber mechanosensitive neurons in bladder function and urologic disease phenotypes, with focus on urologic chronic pelvic pain syndrome (UCPPS). The research team has developed new tools for...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beth Israel Deaconess Medical Center $1.552 million on September 9, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to map mechanosensory circuits from the bladder to Barrington's nucleus. The recipient will use immediate early gene activity, RNA sequencing, fiber photometry, and cellular-resolution calcium imaging to identify central nervous system nuclei and cell...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Houston System $167,696 on August 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop intelligent bioelectronic implants for diagnosis and neuromodulation of neurogenic bladder dysfunction. The award funds research to address urological dysfunction following spinal cord injury, particularly neurogenic bladder and detrusor sphincter...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Medical College of Wisconsin, Inc. a Project Grant of $432,625 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop animal models and resources for preclinical lower urinary tract research. The award, effective August 6, 2025, through July 31, 2027, supports the creation of a comprehensive dataset measuring urological...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Medical College of Wisconsin, Inc. $108,968 on February 17, 2027, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate neural mechanisms governing resting metabolic rate and cardiovascular function. The research focuses on cardiometabolic control by angiotensin II type 1 receptor-expressing agouti-related peptide neurons in the arcuate nucleus of the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $762,423 to the Regents of the University of Michigan on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and optimize quantitative magnetic resonance fingerprinting (MRF) technology for non-invasive assessment of bladder wall tissue characteristics in neurogenic lower urinary tract dysfunction. The research addresses limitations of current...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Rancho Research Institute $727,810 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate functional and structural brain connectivity alterations in post-stroke lower urinary tract dysfunction and to identify biomarkers predicting response to transcutaneous spinal cord stimulation therapy. The research combines three integrated aims. Aim 1 uses...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Davis $1,608,986 on June 9, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research on angiogenesis and vascularization for bioengineered bladder wall regeneration and replacement. The research addresses surgical complications in patients with neuropathic bladder from spina bifida or spinal cord injury who currently undergo...
- The National Institute of Neurological Disorders and Stroke awarded The Medical College of Wisconsin, Inc. $351,840 on June 16, 2026, to develop viral-mediated optogenetic techniques for peripheral nerve stimulation of motor function under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project examines optogenetic nerve stimulation as a method to restore muscle activity and movement, addressing challenges specific to the peripheral...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Medical College of Wisconsin, Inc. $747,444 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms and optimization of tibial nerve stimulation in treating neurogenic bladder dysfunction. The research maps neural connections between the tibial nerve and the lower urinary tract to understand how stimulating a nerve at the ankle impacts bladder function and whether changes to stimulation parameters could improve therapeutic efficacy. The work employs virus-based anatomical mapping in both naive rats and those with spinal cord injury (T9 contusion), functional mapping via stimulation-induced C-FOS activity, and single-nucleus RNA sequencing with machine learning to identify spinal cord cell types responsive to chronic tibial nerve stimulation. The findings are expected to inform future circuit dissection studies and enable improved selection of neuromodulation strategies for individuals with bladder dysfunction due to spinal cord injury. Performance occurs in Wauwatosa, Wisconsin, with a period of performance extending from September 1, 2026, through May 31, 2031. The award is classified as a Project Grant, a mechanism supporting extramural basic and clinical biomedical research that advances prevention, diagnosis, and treatment of diabetes, digestive, and kidney diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $747.4k | 8/26/26 |