Project Grant K25DK144708
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beth Israel Deaconess Medical Center $1.552 million on September 9, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to map mechanosensory circuits from the bladder to Barrington's nucleus. The recipient will use immediate early gene activity, RNA sequencing, fiber photometry, and cellular-resolution calcium imaging to identify central nervous system nuclei and cell...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Medical College of Wisconsin, Inc. $747,444 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms and optimization of tibial nerve stimulation in treating neurogenic bladder dysfunction. The research maps neural connections between the tibial nerve and the lower urinary tract to understand how stimulating a nerve at the ankle...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $762,423 to the Regents of the University of Michigan on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and optimize quantitative magnetic resonance fingerprinting (MRF) technology for non-invasive assessment of bladder wall tissue characteristics in neurogenic lower urinary tract dysfunction. The research addresses limitations of current...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Rancho Research Institute $727,810 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate functional and structural brain connectivity alterations in post-stroke lower urinary tract dysfunction and to identify biomarkers predicting response to transcutaneous spinal cord stimulation therapy. The research combines three integrated aims. Aim 1 uses...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Board of Regents of Nevada System of Higher Education, operating as University of Nevada, Reno, $734,999 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the molecular mechanisms of spinal cord injury-induced detrusor overactivity. The award funds research characterizing how apoptosis of platelet-derived growth factor receptor...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Medical College of Wisconsin $751,694 on April 21, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to optimize chronic tibial nerve stimulation (TNS) for treating neurogenic bladder dysfunction in individuals with spinal cord injury. The research investigates unanswered questions about TNS therapy dosing parameters, intervention timing, and long-term effectiveness...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Davis $1,608,986 on June 9, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research on angiogenesis and vascularization for bioengineered bladder wall regeneration and replacement. The research addresses surgical complications in patients with neuropathic bladder from spina bifida or spinal cord injury who currently undergo...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $713,227 to the University of Wisconsin–Madison on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK146259). The award funds research on the role of A-fiber mechanosensitive neurons in bladder function and urologic disease phenotypes, with focus on urologic chronic pelvic pain syndrome (UCPPS). The research team has developed new tools for...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Minnesota Healthsolutions Corporation $1,068,096 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and evaluate a prototype novel bladder catheterization device. The device addresses a critical clinical gap in urologic management. Over one million Americans—including more than 250,000 people with spinal cord injury, 120,000 with spina bifida,...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Regents of the University of California, San Francisco $512,595 on April 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to define neural circuits controlling urinary and fecal continence and to translate preclinical research toward human health applications. The research leverages mouse models to map and characterize a direct neural circuit between...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Houston System $167,696 on August 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop intelligent bioelectronic implants for diagnosis and neuromodulation of neurogenic bladder dysfunction. The award funds research to address urological dysfunction following spinal cord injury, particularly neurogenic bladder and detrusor sphincter dyssynergia, where the external urethral sphincter fails to relax during detrusor muscle contraction, resulting in inefficient bladder emptying. Current treatments—pharmacotherapy, botulinum toxin injections, and electrical stimulation—provide only temporary relief and do not restore full lower urinary tract control. The project integrates bioelectronics with AI-driven systems to develop soft, highly expandable microelectronic systems for continuous bladder monitoring and autonomous closed-loop neuromodulation. Specific research objectives include fabricating a stretchable microelectronic system for monitoring and electrical neuromodulation, developing an intelligent wireless control system for autonomous stimulation, and assessing neurogenic bladder dysfunction in spinal cord injury animal models while investigating neuromodulation effects on preventing detrusor sphincter dyssynergia. The award runs through May 31, 2031, with place of performance in Houston, Texas 77204. This is a K25 project grant, a career development award supporting the principal investigator's transition toward independent investigation at the intersection of bioengineering and urology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $167.7k | 8/27/26 |