Project Grant R01DK145103
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $803,748 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 5, 2025, through June 30, 2029. This research project investigates the modulation of insulin signaling in adipocytes to address systemic metabolic dysfunction. The research employs a...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a Project Grant award of $149,264.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective April 5, 2026, with a completion date of December 31, 2028. The grant funds basic biomedical research investigating the role of GA-binding protein (GABP) in pancreatic beta cell...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $786,216 Project Grant to the University of California, Los Angeles (UCLA) on August 28, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports a four-year research initiative (through June 30, 2029) investigating post-transcriptional regulation of hepatokines and systemic metabolism. The research focuses on identifying...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Pennsylvania a $787,367 Project Grant on September 9, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to map the gene regulatory architecture of pancreatic islet-specific cell types in relation to diabetes. The project, scheduled for completion by June 30, 2030, will create the largest integrated map of islet cell...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of North Carolina at Chapel Hill a $1.62 million Project Grant (CFDA 93.847: Diabetes, Digestive, and Kidney Diseases Extramural Research) on September 22, 2025, for a project period extending through June 30, 2030. The grant funds development of resources to interpret genetic signals and identify multi-tissue regulatory mechanisms underlying type 2 diabetes (T2D) and...
- Federal Project Grant Award Summary The University of Texas Health Science Center at San Antonio received a $775,865 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 10, 2025, through July 31, 2030. The award supports basic and clinical biomedical research investigating glucagon-mediated glycemic effects in humans with and...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $1,262,595 Project Grant award effective August 1, 2025, through March 31, 2030, from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This award supports basic biomedical research investigating the regulation of ghrelin secretion by the sympathetic nervous system (SNS). The...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $1,264,088 to the Beckman Research Institute of the City of Hope on July 21, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support fundamental research on epigenetic regulation of genomic stability in beta-cell homeostasis through April 30, 2030. The primary research deliverable involves elucidating mechanisms by which...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $639,990 to The University of Texas Health Science Center at San Antonio under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for a Project Grant commencing May 1, 2026, and concluding January 31, 2031. The research focuses on elucidating the role of oxidized phospholipids (OXPLs) in the pathogenesis of metabolic dysfunction-associated...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Johns Hopkins University $819,091 on September 11, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research on glucose patterns and clinical outcomes in the Dallas Heart Study. The project, extending through June 30, 2030, utilizes continuous glucose monitoring (CGM) systems and machine learning methods to...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The University of Texas Health Science Center at San Antonio a $707,781 Project Grant on May 22, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This award, which extends through March 31, 2031, funds research to identify cell type-specific insulin-responsive quantitative trait loci (QTLs) in human skeletal muscle. The project will employ advanced molecular profiling techniques, including single nuclei RNA sequencing (snRNA-seq) and assay for transposase-accessible chromatin with sequencing (ATAC-seq), to characterize dynamic molecular responses to insulin stimulation during hyperinsulinemic-euglycemic clamp procedures. The research aims to mechanistically link non-coding genetic variation associated with type 2 diabetes to downstream effects on the epigenome and gene expression within specific skeletal muscle cell types. By identifying response expression QTLs (r-eQTLs) and response chromatin accessibility QTLs (r-cAQTLs) that are acutely sensitive to insulin, the project will advance understanding of skeletal muscle insulin resistance—a core pathophysiologic defect in type 2 diabetes that precedes glucose intolerance. The deliverables include molecular QTL identification, functional characterization of disease-associated loci, and potential therapeutic insights relevant to diabetes prevention and management in at-risk populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $707.8k | 5/22/26 |