Project Grant R01DK141843
- The University of Texas Southwestern Medical Center was awarded a $148,575 Project Grant by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) on September 15, 2025. The grant supports research on the role of Fibroblast Growth Factor 1 (FGF1) in regulating lipid homeostasis and atherosclerosis. Specifically, the researchers aim to investigate how FGF1 signaling in adipose tissue, particularly brown adipose tissue, can improve lipid metabolism and insulin...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $410,000.00 to The University of Texas Southwestern Medical Center to study the effects of glucagon-like peptide 1 (GLP-1) receptor agonists and brain-derived GLP-1 on the activity of neuropeptide Y/agouti-related peptide (NPY/AGRP) neurons and their impact on metabolism. The research aims to define the...
- This $804,342 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Duke University to investigate the metabolic actions of glucagon, a hormone that plays a key role in glucose regulation. Specifically, the research aims to characterize how glucagon receptor signaling in the liver engages divergent pathways that...
- This Project Grant award of $3,103,125 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the role of lipogenic pathways in intestinal remodeling after Roux-en-Y gastric bypass surgery. The central hypothesis is that alterations in intestinal epithelial lipid homeostasis, driven by LXR and PPARA signaling, are necessary for Roux limb...
- This federal Project Grant award of $828,771 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to study the neural mechanisms underlying the metabolic benefits of bariatric surgeries, such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB). The key objectives are to employ electrophysiological techniques to analyze changes in neuronal excitability and...
- The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $222,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Beckman Research Institute of the City of Hope. The grant supports research to understand how conjugated bile acids regulate metabolism after bariatric surgery, with the goal of developing safer and more affordable treatments for obesity and fatty liver disease. Key activities include...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,999,512 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The University of Texas Southwestern Medical Center, doing business as Southwestern Medical School. This 4-year award, starting on September 1, 2025, will support research to investigate the regulation of mitochondrial health in mammalian livers, with a focus on understanding the...
- This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how the sympathetic nervous system regulates ghrelin secretion. The $637,124 grant, awarded to the University of Texas Southwestern Medical Center, will fund a 5-year research project to determine how fasting and exercise impact the sympathetic...
- This federal Project Grant award of $802,843, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by Yale University to investigate the relationship between intestinal microbial activity and human metabolism. The key objectives are to: 1) understand how insulin resistance affects the adipose tissue lipolysis response to intestinal...
- This Project Grant award of $2,608,068.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to study the impact of bariatric surgery on skeletal health. The primary objectives are to investigate how changes in gastric secretory factors, such as ghrelin and somatostatin, contribute to bone loss following vertical sleeve gastrectomy (VSG) surgery. The...
The University of Texas Health Science Center at San Antonio received a $775,865 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) on September 10, 2025. The award supports research to investigate the glycemic effects of glucagon in individuals with and without gastric bypass or sleeve gastrectomy surgery. The research aims to measure the impact of exogenous glucagon infusion on endogenous glucose production during hypoglycemic and hyperglycemic conditions in the absence of meal stimuli. This project is expected to enhance understanding of the role of glucagon in glucose physiology and the glycemic effects of these common bariatric surgery procedures.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $775.9k | 9/10/25 |