Project Grant R01DK145006
- This $246,750 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at The Trustees of Columbia University in the City of New York to investigate how obesity affects immune cells in the pancreas and drives pancreatic inflammation. The key objectives are to: 1) Examine how the origin of pancreatic macrophages (embryonic vs. monocyte-derived) influences their...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $163,511 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Illinois to study the effects of dietary fiber supplementation on hypothalamic inflammation and obesity. The research project aims to test the hypothesis that dietary fiber, through short-chain fatty acid signaling, can prevent western diet-induced obesity by reducing...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to study the regulation of metabolic diseases by the human commensal bacterium Clostridium immunis. The overarching goal is to determine the mechanism by which an exopolysaccharide (EPS) secreted by C. immunis decreases visceral adiposity, a key risk factor for type 2 diabetes and...
- This $121,875 Project Grant was awarded on April 5, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the developmental origins and cellular composition of dermal adipose tissue, which plays a critical role in human metabolism and obesity. The central hypothesis is that embryonic formation of dermal adipose tissue is...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $554,874 to Northern Illinois University to investigate the role of the gut-brain-microbiota axis in the relationship between inflammatory bowel disease (IBD) and long-term stress. The goal is to determine how stress-induced changes to the gut microbiome impact the development of...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $784,966 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Brandeis University. The grant will fund research to investigate the cellular and molecular mechanisms by which the enteric nervous system in the nematode C. elegans detects and responds to internal sensory cues related to feeding behavior, gut motility, and physiological adaptation. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $136,449 Project Grant to the University of California, Berkeley under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, awarded on December 1, 2024, will fund research to evaluate the role of human obesity genes in specific neuronal populations in mice using a CRISPR-based approach. The objective is to rapidly test whether genes predisposing humans to obesity...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $176,500.00 to the University of Washington to investigate the links between hypothalamic microglia activation and perineuronal net (PNN) loss in the arcuate nucleus, and how these changes contribute to the pathogenesis of diet-induced obesity and glucose regulation. The...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding a $233,250 research project at Washington University in St. Louis. The project aims to investigate the role of the protein phosphatase 1K (PPM1K) in macrophage activation and its impact on obesity-related metabolic dysfunction. Specifically, the research will examine how macrophages...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,736,640 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Leland Stanford Junior University. The 4-year grant, awarded on September 5, 2025, will support research to characterize the diversity of innate lymphoid cell (ILC) subtypes and define their development, function, and spatial regulation in the gut. The objective is to exploit...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a 5-year, $734,612 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of the University of Pennsylvania. The grant supports research to investigate the mechanisms by which psychological stress and diet-induced obesity in early life can reprogram the functions of monocyte and macrophage populations in response to elevated glucocorticoid levels, leading to increased susceptibility to inflammatory and metabolic diseases. The research aims to elucidate how glucocorticoids regulate monocyte populations in the gastrointestinal tract in response to early life stress and uncover how stress-induced glucocorticoids promote the emergence of inflammatory glia and the reprogramming of their chromatin landscape.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $734.6k | 8/18/25 |