Project Grant R01CA301086
- This $2,970,076 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate the developmental programming of adult intestinal stem cells (ISCs) and how an obesogenic maternal environment during pre- and postnatal development can establish a maladaptive pre-pathological ground state in offspring. Using genetically engineered mouse and organoid models, the...
- This $441,913 federal Project Grant award from the National Cancer Institute's Cancer Cause and Prevention Research program (CFDA 93.393) supports research at Tufts University School of Medicine to investigate obesity-related DNA methylation markers and their association with 13 obesity-related cancer types. The project aims to leverage existing data from the Atherosclerosis Risk in Communities (ARIC) study to identify specific adiposity-related DNA methylation markers linked to...
- The U.S. National Cancer Institute awarded a $724,840 Project Grant to the Regents of the University of California, San Francisco under the Cancer Cause and Prevention Research (CFDA 93.393) federal grant program. The grant supports a 5-year research project to investigate how persistent poverty impacts the risk of colorectal cancer through place-based factors, health behaviors, and underlying biological mechanisms. The study will leverage data from two large, geographically diverse U.S. cohorts...
- The National Cancer Institute (NCI) awarded a $107,071 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) to Rockefeller University, effective March 1, 2025 through February 28, 2029. The grant supports research to investigate the role of inter-organellar communication, specifically between the endoplasmic reticulum and mitochondria, in metabolic reprogramming and cellular plasticity in colorectal cancer. Key objectives include identifying the molecular mechanisms...
- This $192,888 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports a research project at the University of Virginia (UVA) to investigate the use of normal colon organoids for identifying causal genetic variants associated with colorectal cancer risk. The key objectives of the project are to: 1) test the hypothesis that colorectal cancer GWAS genes are cell type-specific, and 2) determine the role of these genes within colon epithelial...
- This $248,998 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) will support research by The General Hospital Corporation (Massachusetts General Hospital) to identify gut microbial and metabolomic biomarkers that link the consumption of ultra-processed foods to colorectal cancer risk. The research will leverage multi-omics data from large prospective cohorts and integrate a medically tailored meal intervention into the oncology care of colorectal...
- This $2,864,671 Project Grant awarded by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to the Regents of the University of Michigan is focused on developing a novel strategy to enzymatically inhibit colibactin, a procarcinogenic metabolite from enteric bacteria associated with colorectal cancer (CRC). The objectives are to: (1) create engineered microbes that can deliver the colibactin inactivation protein ClbS to safely and effectively neutralize colibactin in the gut,...
- This federal Project Grant award of $205,700 from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) supports research at the Sloan-Kettering Institute for Cancer Research in New York aimed at understanding and overcoming rapid resistance to targeted therapies in colorectal cancer. The key objectives are to evaluate how intrinsic tumor features modulate the development of resistance to targeted therapies, and to test a novel combination approach to...
- The National Cancer Institute (NCI), under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded a $231,710 Project Grant to Arizona State University (ASU) to develop AI-powered measures of pedestrian environment features (PEFs) for studying the relationship between physical activity (PA) and cancer prevention in rural communities. The project aims to: 1) validate existing machine learning algorithms to assess 9 microscale PEFs (e.g., sidewalks, crosswalks, lighting) in rural...
- The National Cancer Institute (NCI) awarded a $637,596 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to test a video-based intervention designed to reduce defensive colorectal cancer information avoidance and increase colorectal cancer screening rates. The 5-year project will conduct a randomized controlled trial to confirm the intervention's mechanisms of increasing self-efficacy and positive affect, and evaluate its efficacy in reaching those who tend to...
The National Cancer Institute (NCI) awarded a $621,570 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to Arizona State University (ASU) on August 8, 2025. The grant supports research to determine the impact of maternal obesity on the transformative risk of colorectal cancer (CRC) in offspring by directly assessing the developmental programming of intestinal stem cells during pre- and postnatal growth. The research aims to investigate how naive exposure to an obesogenic maternal environment establishes a pro-tumorigenic ground state in the offspring's intestinal stem cells. Using genetically engineered mouse and organoid models, the project will distinguish intrinsic adaptations and extrinsic environmental interactions that drive this developmental programming and influence CRC risk. The funding will enable ASU to conduct this comprehensive research over a 5-year period, with a targeted completion date of July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $621.6k | 8/7/25 |