Project Grant R01DK143098
- Federal Grant Award Summary The University of Pennsylvania received a $734,612 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective August 18, 2025, with completion targeted for June 30, 2030. This research project investigates the mechanisms through which early-life glucocorticoid exposure—induced by psychological stress and diet-induced...
- Federal Grant Award Summary The University of Pennsylvania received a $446,875 Project Grant awarded on August 11, 2025, by the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research investigating the role of mast cell G-protein coupled receptors in immune modulation of ulcerative colitis, a subtype of inflammatory bowel disease. The research utilizes CRISPR/Cas9-mediated gene editing to...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Pennsylvania State University a $264,013 Project Grant on June 19, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This research award funds an investigative study into the genetic, symbiotic, and evolutionary bases of the human gut mycobiome—specifically examining how human genetic variants, gut bacterial communities, and hominid...
- Federal Project Grant Award Summary Mayo Clinic received a $2.84 million Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 22, 2025, through September 21, 2029. The grant funds basic and translational research to investigate genetic regulation of epithelial injury in ulcerative colitis (UC), a chronic inflammatory bowel disease...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded University of Colorado-Denver a $2,076,999 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on September 15, 2025, with a completion date of September 14, 2029. This four-year research initiative focuses on investigating paneth cell mitochondrial dysfunction and its role in intestinal homeostasis, with particular emphasis on...
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received a $188,538 project grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective August 1, 2025, with a completion date of April 30, 2030. The award supports research focused on developing personalized biomarkers for ulcerative colitis (UC) treatment by establishing a...
- Federal Grant Award Summary The University of Pennsylvania received a $3.23 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded on September 15, 2025, with a completion date of August 31, 2029. This research grant supports a four-year investigation into mitochondrial dysfunction mechanisms driven by splicing factor mutations in...
- Federal Grant Award Summary The University of Chicago received a $184,572 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective June 15, 2025, with a completion date of March 31, 2030. The research initiative focuses on characterizing the transmural nature of ulcerative colitis (UC) through intestinal ultrasound imaging to identify...
- Federal Grant Award Summary The University of Pennsylvania received a $153,956 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective January 10, 2026 through July 9, 2027. This research project investigates the role of the RNA binding protein HNRNPK (heterogeneous nuclear ribonucleoprotein K) in pancreatic beta cell dysfunction associated with...
- Federal Grant Award Summary The University of Pennsylvania received a $787,367 project grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 9, 2025, with completion targeted for June 30, 2030. This award supports the development of comprehensive mapping of pancreatic islet cell types and their gene regulatory architecture to advance diabetes...
Pennsylvania State University, operating as Penn State Milton S. Hershey Medical Center, received a $708,697 Project Grant awarded March 1, 2026, through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds basic biomedical research investigating the mechanisms of inflammatory activation of mesenchymal cells in ulcerative colitis (UC), with performance at the Hershey, Pennsylvania facility through December 31, 2029. The research deliverables focus on elucidating how mesenchymal fibroblasts become pathologically activated in UC through JAK/STAT signaling pathways and dysbiotic microbial interactions. The project aims to identify mechanisms underlying the abnormal differentiation of mesenchymal stem cells into inflammatory fibroblasts and to understand why approximately 50 percent of UC patients relapse following mesenchymal stem cell therapy. By clarifying these pathogenic mechanisms, the research is intended to advance therapeutic development and improve treatment outcomes for patients with UC, addressing a critical gap in understanding chronic intestinal inflammation that currently lacks curative options.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $708.7k | 2/18/26 |