Project Grant R01DK141679
- This $184,572 project grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to characterize the transmural nature of ulcerative colitis (UC) and its associated disease-related outcomes using intestinal ultrasound. The research will test the hypothesis that transmural structural alterations to the bowel wall in UC lead to poor clinical outcomes, and...
- This federal Project Grant award in the amount of $188,538 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The primary goal of the project is to establish a framework linking macrophage transcriptomic states with chromatin structure in order to develop personalized biomarkers for ulcerative colitis, a complex inflammatory bowel disorder. The research,...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $358,039 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Nous Biosciences Inc., a small disadvantaged business located in Pennsylvania. The grant supports research to evaluate a combination therapy of the guanylate cyclase-C agonist dolcanatide and the JAK-STAT inhibitor atiprimod for the treatment of murine colitis. The research aims to explore...
- This $151,643 Project Grant, awarded on April 11, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), supports research at the University of Colorado-Denver to develop Proteolysis Targeting Chimeras (PROTACs) that regulate the Hypoxia Inducible Factor (HIF) pathway to treat inflammatory bowel disease (IBD). The research aims to design HIF-stabilizing PROTACs and elucidate their effects on epithelial barrier formation and wound healing, with the goal of...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $191,547 to Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) to conduct research on targeting the gut mycobiome in ulcerative colitis. The key objectives are to: 1) evaluate the mycobiome as a predictor of biologic-treatment failure, 2) identify competitive...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,736,640 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Leland Stanford Junior University. The 4-year grant, awarded on September 5, 2025, will support research to characterize the diversity of innate lymphoid cell (ILC) subtypes and define their development, function, and spatial regulation in the gut. The objective is to exploit...
- This federal Project Grant award of $234,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research at the University of Colorado-Denver to investigate the role of the transcriptional regulator Aiolos in regulating T cell activation and its contribution to the pathogenesis of inflammatory bowel disease (IBD). The project aims to utilize CRISPR-Cas9 genome editing to study how...
- The federal Project Grant award of $458,047 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate how extracellular vesicles (EVs) from intestinal epithelial cells (enterocytes) mediate cell-to-cell communication and function as effectors of inflammation in inflammatory bowel disease (IBD). The project seeks to identify the transcriptomic miRNA signature of EVs produced by...
- This Project Grant award of $228,948.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of the neuropeptide adrenomedullin 2 (ADM2) in regulating intestinal inflammation and promoting tissue protection. The research, conducted by Weill Medical College of Cornell University, aims to elucidate how the ADM2-ADM2 receptor pathway...
- This federal Project Grant award of $2,076,999.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at the University of Colorado-Denver to investigate the role of mitochondrial dysfunction in Paneth cells and its relationship to inflammatory bowel diseases such as Crohn's disease. Key objectives include understanding how...
This federal Project Grant award of $2,842,245 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, aims to elucidate intestinal epithelial cell (IEC) injury pathways that govern anti-TNF therapy effectiveness in ulcerative colitis, and to discover predictive biomarkers in formalin-fixed, paraffin-embedded (FFPE) biopsies indicative of anti-TNF treatment outcome. The research will employ an innovative mouse model and spatial transcriptomics analysis of archived FFPE patient biopsies, complemented by in vitro assays using colonic organoids, to characterize primary IEC responses and identify therapy response signatures. This award will support this critical unmet need for aligning ulcerative colitis patients with effective treatment options through the development of cytoprotective strategies and predictive biomarkers.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.8m | 9/22/25 |