Project Grant R01DK142845
Award Date
7/1/25
Completion Date
4/30/30
Dollars Obligated
$647K
Similar Awards
This Project Grant award of $117,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of substance P-mediated activation of mast cells in driving visceral hypersensitivity and barrier dysfunction in irritable bowel syndrome (IBS). The objective is to delineate the underlying mechanisms of bidirectional crosstalk between sensory...
This federal Project Grant award of $726,140.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the neural circuits and cellular mechanisms underlying visceral pain processing in the spinal cord and brainstem, with the goal of advancing understanding and treatment of visceral pain conditions such as irritable bowel syndrome,...
This Project Grant award of $1,461,766.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research on the molecular and cellular mechanisms underlying visceral pain and cross-organ sensitization. The research will focus on understanding the role of MRGPRB2+ mast cell-TRPV1+ nociceptor clusters in bladder pain and bladder-colon cross-sensitization. Key...
This $625,060 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to elucidate the roles of distinct spinal cord cell types in mediating interstitial cystitis (IC)/bladder pain syndrome (BPS). The research, conducted by The Washington University in St. Louis, will use chemogenetics and optogenetics approaches to determine the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a 5-year research program focused on defining novel neuro-immune pathways that regulate gut physiology. The $168,296 award to Weill Medical College of Cornell University aims to investigate the role of enzymes in group 3 innate lymphoid cells (ILC3s) and their impact on inflammatory bowel disease (IBD) and...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $632,204 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Mayo Clinic to conduct a pilot, randomized, double-blind, placebo-controlled clinical trial. The trial will investigate the efficacy and safety of proteolytic activity-guided fecal microbiota transplantation (FMT) for treating irritable bowel syndrome (IBS), specifically the post-infection IBS...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, provides $196,940 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct a 5-year research project on a positive psychology intervention for irritable bowel syndrome (IBS). The key products and services to be delivered under this award include: 1)...
This federal Project Grant award of $524,837 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is supporting research to investigate the role of enteric glial mechanotransduction and the impact of mechanical stress on postoperative ileus (POI) and postoperative gastrointestinal dysfunction (POGD). The research aims to better understand the pathogenic mechanisms of POI in...
The National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases awarded a $152,205 Project Grant to The Regents of the University of California San Francisco under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds research to investigate how vagal sensory neurons regulate autonomic responses to achieve metabolic homeostasis, and how downstream neuronal circuits in the nucleus tractus solitarius integrate...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...