Project Grant R01DK142682
Award Date 9/15/25
Completion Date 7/31/30
Dollars Obligated $837K
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
- This $1,558,188 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The project, led by researchers at the University of Pennsylvania, will utilize advanced...
- This federal Project Grant award of $465,444.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how commensal fungi in the gut can promote intestinal wound repair. The research aims to mechanistically understand how fungi modulate epithelial cells and fibroblasts to enhance crypt regeneration, with a focus on identifying the...
- This federal Project Grant award of $155,443 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research on the role of blood vessel endothelial cells in intestinal regeneration and inflammatory bowel disease. Led by Dr. Brisa Palikuqi at Yale University, the research utilizes mouse models, immune profiling, single cell RNA sequencing, and spatial transcriptomics...
- This $2,970,076 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate the developmental programming of adult intestinal stem cells (ISCs) and how an obesogenic maternal environment during pre- and postnatal development can establish a maladaptive pre-pathological ground state in offspring. Using genetically engineered mouse and organoid models, the...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $224,088 Project Grant to the Regents of the University of Michigan (University of Michigan) to conduct research aimed at elucidating the mechanisms of Notch signaling in immature and adult intestinal stem cells. The research will investigate how intestinal stem cells maintain Notch signaling and regulate stem cell...
- This federal Project Grant award of $580,568, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the role of the CD45 tyrosine phosphatase in regulating neutrophil function and intestinal inflammation. The research aims to elucidate the effects of neutrophil-specific loss of CD45 on intestinal inflammation and repair, as well as how CD45...
- This $2,618,975 Project Grant was awarded on September 8, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports a 5-year research project led by the University of Texas Health Science Center at Houston to advance the development and functional capabilities of tissue-engineered intestine as a potential cure...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research provides $115,288 to the University of North Carolina at Chapel Hill (UNC-CH) to support research on transcriptional regulation of mitochondrial metabolism in human intestinal stem cells. The principal investigator, Dr. Joseph Burclaff, is mentored by Dr. Scott Magness. The project aims to determine how the...
- This federal Project Grant award, with a total funding amount of $645,617, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is aimed at understanding the dysfunction of hematopoietic stem cells in refractory Crohn's disease, a condition that is resistant to traditional treatments. The research will profile hematopoietic stem cell populations...
- This federal Project Grant award of $147,486 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research to investigate the role of gut microbes in regulating interleukin-22 (IL-22) levels in the pancreas and the impact on pancreatic health and disease. The research aims to determine how gut microbe-induced IL-22 affects pancreatic gene expression and the underlying cellular mechanisms, as well as the beneficial and detrimental effects of this...