Project Grant R01DK142751
- This federal Project Grant award of $147,486 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research to investigate the role of gut microbes in regulating interleukin-22 (IL-22) levels in the pancreas and the impact on pancreatic health and disease. The research aims to determine how gut microbe-induced IL-22 affects pancreatic gene expression and the underlying cellular mechanisms, as well as the beneficial and detrimental effects of this...
- This $146,922 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The University of Pittsburgh is conducting research to investigate the role of gut protist-derived compounds on dietary antigen presenting dendritic cells in celiac disease. The project aims to understand how certain gut microbes can protect against virus-mediated loss of oral...
- This $164,188 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The 5-year grant supports training and research at the University of Washington to study the role of intestinal chondroitin sulfate glycosaminoglycans in inflammatory bowel disease. The research aims to determine how changes in the composition of these gut matrix...
- This Project Grant award of $191,547 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research conducted by Tufts Medical Center to evaluate the role of the gut mycobiome (fungal microbiome) in ulcerative colitis. The key objectives are to: 1) assess whether persistent elevations in the fungus Candida albicans in the gut predict failure of biologic therapies in ulcerative colitis...
- This federal Project Grant award of $790,359, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The research project aims to design, characterize, and optimize a fibronectin-targeting, nanobody...
- This federal Project Grant award for $836,942 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research into the role of autophagy (self-digestion) in intestinal regeneration and stem cell activity. The research aims to investigate how autophagy contributes to injury resistance and the ability of certain intestinal cell types to re-acquire stem cell-like...
- This $1,554,672 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to define the molecular mechanisms underlying gut inflammation and barrier dysfunction in people living with HIV. The grant supports research led by The Washington University in Missouri to establish a novel humanized mouse model that can faithfully recapitulate HIV infection in...
- This $233,250 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to understand how macrophage branched chain amino acid (BCAA) metabolism contributes to obesity-related metabolic dysfunction. The project, led by The Washington University, will investigate the role of the enzyme protein phosphatase 1K (PPM1K) in regulating macrophage BCAA metabolism and...
- This federal Project Grant award of $161,695 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of purinergic signaling in intestinal inflammation and wound healing. The principal objective is to elucidate how the purinergic receptor P2Y1 expressed in intestinal epithelial cells influences the inflammatory response and repair processes during colitis. The research...
- This federal Project Grant award of $242,100.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will support research by Mayo Clinic to investigate the role of sphingolipid metabolism in regulating regulatory T cell function and intestinal homeostasis, with the goal of developing new therapeutic strategies for inflammatory bowel disease. The project...
This federal Project Grant award of $465,444.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how commensal fungi in the gut can promote intestinal wound repair. The research aims to mechanistically understand how fungi modulate epithelial cells and fibroblasts to enhance crypt regeneration, with a focus on identifying the fungal-derived lipid metabolite palmitoylethanolamide (PEA) as a key regulator of this process. The award was granted to The Washington University, a leading academic research institution, to conduct this investigation using murine models, single-cell RNA sequencing, primary cell cultures, and metabolomics. Successful completion of this 5-year project, which began on September 15, 2025, has the potential to uncover novel targets for stimulating crypt regeneration in inflammatory conditions of the gastrointestinal tract.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $465.4k | 9/8/25 |