Project Grant R01DK142171
- This $780,853 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) aims to investigate the impact of a glucagon-like peptide-1 receptor agonist on simian immunodeficiency virus (SIV)/human immunodeficiency virus (HIV) pathogenesis and antiretroviral therapy (ART) administration in people living with HIV. The project, to be conducted by the University of Pittsburgh from April 2025 through March 2030, will assess changes in T-cell and...
- This $451,000 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research to investigate the role of microRNAs in adipose tissue from people with HIV who develop type 2 diabetes. The project aims to evaluate microRNA expression in adipose tissue and explore whether circulating microRNAs in plasma could serve as biomarkers of risk...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,778,953 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Minnesota. The award, with a start date of September 16, 2025 and a completion date of June 30, 2029, will support research on the dynamics of the HIV reservoir and its association with metabolic complications of HIV infection in individuals receiving...
- This $802,363 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund a research study at Emory University from September 2025 to June 2030 to develop models for predicting the benefits of GLP-1 receptor agonist (GLP-1RA) treatments in preventing obesity-related cardiometabolic diseases. The study aims to use clinical...
- This $1,554,672 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to define the molecular mechanisms underlying gut inflammation and barrier dysfunction in people living with HIV. The grant supports research led by The Washington University in Missouri to establish a novel humanized mouse model that can faithfully recapitulate HIV infection in...
- This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to utilize the ex vivo rectal explant challenge model to evaluate HIV-1 transmitted/founder (T/F) virus replication and inflammation within human gut mucosal tissue. The $430,375 award, effective from September 19, 2025 to September 18, 2027, supports research at Emory University to...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $322,800 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Mayo Clinic in Minnesota. This randomized, placebo-controlled trial will examine the effects of long-acting GLP-1 or dual incretin (GLP-1 and GIP) modulation on gastrointestinal functions and their relationship to weight loss. The research aims to investigate the heterogeneous effects of...
- The University of Texas Health Science Center at San Antonio received a $775,865 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) on September 10, 2025. The award supports research to investigate the glycemic effects of glucagon in individuals with and without gastric bypass or sleeve gastrectomy surgery. The research aims to measure the impact of exogenous glucagon...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $410,000.00 to The University of Texas Southwestern Medical Center to study the effects of glucagon-like peptide 1 (GLP-1) receptor agonists and brain-derived GLP-1 on the activity of neuropeptide Y/agouti-related peptide (NPY/AGRP) neurons and their impact on metabolism. The research aims to define the...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $614,420 to the Hennepin Healthcare Research Institute (HHRI) to test the effectiveness of the Diabetes Homeless Medication Support (D-HOMES) program on improving glycemic control among adults living with type 2 diabetes who have experienced homelessness. The D-HOMES program...
This Project Grant award, totaling $966,521, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding will support a clinical trial titled "INCRETIN MICRODOSING FOR CARDIOMETABOLIC HEALTH IN PEOPLE WITH HIV: THE REINFORCE TRIAL" at the University of Texas Health Science Center at Houston (UTHealth). The project aims to determine the preliminary efficacy of semaglutide microdosing in maintaining weight and cardiometabolic benefits in people living with HIV, following an initial induction therapy phase. Additionally, the study will assess the tolerability and acceptability of the semaglutide induction and microdosing regimens in this population. This work is intended to address critical knowledge gaps regarding strategies to maintain the benefits of long-acting glucagon-like peptide-1 receptor agonists after initial treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $966.5k | 9/10/25 |