Project Grant R01DK140931

Award Date 4/10/25
Completion Date 3/31/30
Dollars Obligated $781K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to define the cellular and molecular processes underlying adipose tissue dysfunction associated with Integrase Strand Transfer Inhibitor (INSTI)-based antiretroviral therapy. The $707,929 award, to be completed by June 30, 2029, will investigate how INSTI drugs, particularly...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a 5-year, $700,000 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to The Regents of the University of California, San Francisco (UCSF) to assess the interrelationship between adipose tissue thermogenesis and fibrosis in the metabolic health of people living with HIV (PLWH). The research aims to: 1) examine how the loss of CD81+ adipogenic precursor cells, which control...
This $788,400 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program supports a longitudinal study on the impact of HIV on the progression to postpartum prediabetes and type 2 diabetes in low-income women in India. The study aims to estimate the time to progression to postpartum prediabetes and type 2 diabetes in 180 women with a history of gestational diabetes,...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $659,199 to the University of Pittsburgh to investigate a novel pathway by which a protein called GDF15 can improve obesity-associated insulin resistance independent of changes in body weight. The research aims to determine whether hepatocyte-derived GDF15 directly modulates...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a 4-year, $410,000 Project Grant titled "Acute and Chronic Effects of GLP-1R Agonism on NPY/AGRP Neuronal Activity" to The University of Texas Southwestern Medical Center. This research, funded under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program, aims to examine how glucagon-like peptide-1 receptor (GLP-1R) agonists and neuronal activity in the nucleus tractus...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $206,283 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), with a performance period from August 16, 2024 to July 31, 2029. The grant will fund research to investigate the effects of targeting immune activation and intestinal barrier function on cardiovascular disease, obesity, and diabetes...
This federal Project Grant award, totaling $872,684.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The goal of the project is to use single-cell multi-omic profiling techniques to investigate the role of transcriptionally active HIV-infected cells in driving chronic immune activation, despite effective antiretroviral therapy (ART). The research aims to identify and characterize the...
This Project Grant award, totaling $864,735, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The goal of this research project is to identify novel mechanisms for generating antiretroviral antibody responses, with a focus on characterizing an alternative, Toll-like Receptor 7 (TLR7)-independent pathway for producing retrovirus-neutralizing antibodies. The University of Pittsburgh, a...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program, supports research to investigate the mechanisms by which defective HIV proviruses in CD4+ T cells and macrophages perpetuate chronic inflammation and contribute to HIV comorbidities. The total funding amount is $765,274, and the award period runs from August 22, 2024 to June 30, 2029. The research aims to: 1) determine...
This Project Grant award, valued at $3,800,169.08 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research into the development of anti-proliferative therapies to limit long-term persistence of the HIV reservoir. The award aims to identify and optimize anti-proliferative drug regimens that can be administered early in the course of HIV/SIV infection to reduce the size and alter...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $780,853 to the University of Pittsburgh to investigate the impact of a glucagon-like peptide-1 (GLP-1) receptor agonist on simian immunodeficiency virus (SIV)/human immunodeficiency virus (HIV) pathogenesis and antiretroviral therapy (ART) in people living with HIV. The research aims to understand how SIV/HIV and ART cause adipose tissue infiltration and dysfunction, leading to inflammation, metabolic disease, and persistence of the viral reservoir. The study will assess the effects of the GLP-1 agonist on modulating adipose tissue size, lipid composition, and immune cell function, with the goal of alleviating or preventing the adverse metabolic effects induced by ART. The award period runs from April 10, 2025, to March 31, 2030.

Generated 4/29/25, 2:55 AM