Project Grant R01DK141541
- This Project Grant award of $2,608,068.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to study the impact of bariatric surgery on skeletal health. The primary objectives are to investigate how changes in gastric secretory factors, such as ghrelin and somatostatin, contribute to bone loss following vertical sleeve gastrectomy (VSG) surgery. The...
- This Project Grant award of $3,103,125 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the role of lipogenic pathways in intestinal remodeling after Roux-en-Y gastric bypass surgery. The central hypothesis is that alterations in intestinal epithelial lipid homeostasis, driven by LXR and PPARA signaling, are necessary for Roux limb...
- The University of Texas Health Science Center at San Antonio received a $775,865 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) on September 10, 2025. The award supports research to investigate the glycemic effects of glucagon in individuals with and without gastric bypass or sleeve gastrectomy surgery. The research aims to measure the impact of exogenous glucagon...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $176,500.00 to the University of Washington to investigate the links between hypothalamic microglia activation and perineuronal net (PNN) loss in the arcuate nucleus, and how these changes contribute to the pathogenesis of diet-induced obesity and glucose regulation. The...
- The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $222,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Beckman Research Institute of the City of Hope. The grant supports research to understand how conjugated bile acids regulate metabolism after bariatric surgery, with the goal of developing safer and more affordable treatments for obesity and fatty liver disease. Key activities include...
- This Project Grant award of $325,408 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports the development of an easy-to-operate endoscopic automatic gastroplasty device that mimics the effect of gastric bypass/bariatric surgery. The device is intended to provide a minimally invasive, non-surgical weight loss solution for the treatment of diabetes and obesity. The technology creates a reinforced circular plication of stomach tissue to reduce the stomach...
- This $1,280,753 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research on the role of hypothalamic SH2B1 neurocircuits and SH2B1 signal transduction pathways in obesity and metabolic disease. The research, conducted by the Regents of the University of Michigan, aims to identify SH2B1-expressing neurons in the paraventricular hypothalamus (PVH) that control...
- The National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases awarded a $152,205 Project Grant to The Regents of the University of California San Francisco under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds research to investigate how vagal sensory neurons regulate autonomic responses to achieve metabolic homeostasis, and how downstream neuronal circuits in the nucleus tractus solitarius integrate...
- This Project Grant award of $249,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to New York University aims to improve understanding of how hunger and satiety neurons regulate the activity of downstream neurons in the hypothalamus. Specifically, the research will use novel molecular and optical tools to measure and manipulate cyclic AMP (cAMP) signaling in paraventricular hypothalamic neurons that express melanocortin-4 receptors (PVHMC4R), which...
- This Project Grant award, valued at $747,133.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by the Monell Chemical Senses Center to behaviorally, physiologically, anatomically, and molecularly characterize a population of neurons in the nucleus tractus solitarius (NTS) that express glucagon-like peptide-1 receptors (GLP1R) and...
This federal Project Grant award of $828,771 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to study the neural mechanisms underlying the metabolic benefits of bariatric surgeries, such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB). The key objectives are to employ electrophysiological techniques to analyze changes in neuronal excitability and synaptic physiology of specific arcuate neurons before and after bariatric surgery, as well as to investigate the contribution of these neurons to the metabolic improvements observed. The research will also explore molecular alterations in the differential responses of these neuron populations based on the type of bariatric procedure. This work aims to enhance the understanding of the intricate mechanisms and cell populations involved in the metabolic benefits induced by bariatric surgery, with potential to inform the development of targeted interventions for obesity and associated metabolic disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $828.8k | 9/15/25 |