The federal Project Grant award R01DK137207, totaling $1,267,500.00, was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to generate pilot and feasibility data required to design and lead a definitive clinical trial evaluating the use of combination therapy with levothyroxine (LT4) and triiodothyronine (LT3) for the treatment of hypothyroidism....
This federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $172,003 award supports a 5-year research project titled "Redefining and Improving Hypothyroidism Care Using Real-World Data" at the University of Chicago.
The project aims to: 1) Determine the association between cumulative thyroid stimulating hormone (TSH)...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $999,615 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Extend Biosciences Inc., a woman-owned biotechnology company. The grant funds the development of a long-acting parathyroid hormone (PTH) derivative, EXT608, for the treatment of hypoparathyroidism. The project aims to conduct a Phase 2 clinical trial to evaluate the safety, tolerability,...
This federal Project Grant award, provided by the National Center for Advancing Translational Sciences (NCATS) under CFDA program 93.350, will fund a $145,636 research project at Beth Israel Deaconess Medical Center, Inc. in Boston, Massachusetts. The project aims to evaluate the relationship between intracellular thyroid hormone levels and brown adipose tissue activity, transcriptome, and cellular composition in adult humans. This research seeks to better understand the interaction between...
This Project Grant award of $818,647 from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Johns Hopkins University will support research to understand whether excess thyroid hormone is a preventable risk factor for Alzheimer's disease and related dementias. The 5-year project, running from September 1, 2024 to May 31, 2029, will investigate the relationship over time between thyroid hormone therapy, hormone levels, and the development of dementia in several patient...
This federal Project Grant award, totaling $241,130.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will support research to investigate the "ADAPTIVE RESPONSE(S) TO COMPLETE THYROGLOBULIN GENE KNOCKOUT" at the University of Michigan over the project period from August 16, 2024 to March 31, 2027. This research aims to advance the...
The federal Project Grant award of $720,850, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research Program (CFDA 93.847), will fund a study titled "Improving the Validity of Linked Real-World Data Studies for Diabetes Mellitus Research (VALIDATE-DM)." The study aims to (1) develop systematic approaches to investigate potential biases when using linked real-world data sources for...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), totals $340,747 for the period from September 1, 2024 to July 31, 2027. The award supports research to investigate the cardiometabolic benefits of reducing iatrogenic hyperinsulinemia, a condition caused by delivering insulin into the peripheral circulation rather than the hepatic portal...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $200,220 Project Grant to The Johns Hopkins University under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, awarded on July 15, 2024, with a final completion date of March 31, 2029, will support research on the impact of chronotype (sleep timing preferences) on glucose metabolism in youth. The study aims to investigate whether aligning glucose metabolic...
This $163,344 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Colorado-Denver. The research aims to determine the role of thyroid hormone regulation, specifically type 3 deiodinase (DIO3), in driving sex-specific differences in cardiovascular health outcomes. Key objectives include investigating whether DIO3 expression post-myocardial infarction differs between males and...