This $567,643 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at Duke University to investigate the role of alpha-to-beta cell communication in regulating insulin secretion and glucose homeostasis. The research aims to enhance the understanding of how alpha cells process proglucagon peptides, such as glucagon and GLP-1, to modulate...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the translational programming of beta-cells in response to glucose toxicity. The $724,053 award to the Joslin Diabetes Center in Boston, MA will fund a 3-year project to study the mechanisms by which sustained high glucose levels dysregulate insulin...
This federal Project Grant award for $444,867 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the role of the XBP1 protein in pancreatic beta cell survival and function under metabolic stress. The research aims to elucidate how the XBP1 protein, a key component of the unfolded protein response (UPR), impacts beta cell integrity...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $205,280 to investigate the mechanisms by which pancreatic beta and delta cells coordinate their activity in response to high glucose levels. The research aims to definitively establish the predominant mechanisms of communication between beta and delta cells, whether through...
This $627,809 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on reprogramming glutamine metabolism in pancreatic beta cells to understand and prevent progression to type 2 diabetes. The grant recipient, The Trustees of the University of Pennsylvania, will investigate how the transaminase GPT2 promotes beta cell dysfunction and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $205,280 to the University of California, Davis to investigate the mechanisms driving the kinetics of incretin-mediated beta cell responses. The research aims to improve understanding of incretin signaling, which is critical for developing more effective treatments for type 2 diabetes....
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a longitudinal study using PET/MRI imaging to assess insulin vesicle functional capacity (IVFC) and beta cell mass (BCM) in individuals at risk for and with recent-onset type 1 diabetes. The total award amount is $1,338,684, with a project period from March 13, 2025 to February 28,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $399,545.00 to the University of California, Davis to investigate the role of the signaling protein 14-3-3ζ in regulating islet function and crosstalk between pancreatic α-cells and β-cells. The research aims to determine how 14-3-3ζ inhibition in β-cells impacts glucose-stimulated...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $698,646 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Van Andel Research Institute (VAI) in Grand Rapids, Michigan. The project aims to define the functional and disease relevance of putative beta-cell subtypes in Type 2 Diabetes (T2D). Key objectives include using single-cell epigenomic tools to characterize functionally and...
This $602,531 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the tolerogenic potential of lymph node fibroblastic reticular cells in autoimmune diabetes. The key goals are to: 1) evaluate the impact of modulating the ability of lymph node fibroblastic reticular cells to express and present self-antigens on...