Project Grant R01DK140085
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $175,964 Project Grant to Hepatx Corporation in Palo Alto, CA on May 13, 2025. The grant aims to develop a proteomic assay, or blood test, to monitor the success of cell transplantation therapies, such as hepatocyte (liver cell) transplantation, for treating chronic diseases. This novel assay would enable the...
- This $161,400 Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) supports research by the Mayo Clinic to evaluate the therapeutic benefits of ferroptosis, a novel form of cell death, for treating cholangiocarcinoma (CCA), a highly lethal liver and bile duct cancer. The research aims to elucidate how CCA cells, including those resistant to conventional therapies due to genetic mutations, can be targeted through the induction of...
- This Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $564,900.00 to Mayo Clinic to support research aimed at "EXPLOITING VIRAL TROPISM TO TARGET CANCER-ASSOCIATED FIBROBLASTS IN INTRAHEPATIC CHOLANGIOCARCINOMA". The award period runs from September 1, 2024 to August 31, 2026. Mayo Clinic, a renowned non-profit academic medical center, will leverage its expertise in cancer biology, drug development,...
- This $1,558,188 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The project, led by researchers at the University of Pennsylvania, will utilize advanced...
- This federal Project Grant award for $664,769.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting research conducted by Oregon Health & Science University to develop allogeneic hepatocyte (liver cell) transplantation without the need for immunosuppression. The research aims to overcome key barriers to wider adoption of liver cell therapy,...
- This $564,900.00 Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports advanced biomedical research by Mayo Clinic in Rochester, MN. The project, titled "Targeting the Distinct Immune Microenvironments of Intrahepatic and Perihilar/Distal Cholangiocarcinoma," aims to transform healthcare for military service members, veterans, and the broader public through innovative and impactful research on a rare form...
- This Project Grant award of $1,982,628.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to develop advanced methods for detecting liver fibrosis and creating a predictive diagnostic model for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in primary care settings. The project aims to improve identification of...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the National Institutes of Health, awarded a $292,116 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Renovate Biosciences Inc. The grant aims to generate human livers from donor patient-specific cells using pigs as a "bio-incubator" for xenotransplantation, with the long-term goal of producing immune-compatible solid organs for...
- This $715,501.00 Project Grant awarded on March 15, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at Columbia University's Health Sciences Division. The project aims to investigate the role of T helper cells and stem cells in colon homeostasis and tumor initiation. Key objectives include determining how T cell cytokines modulate colon stem cell...
- This $2,842,245 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the role of intestinal epithelial cell (IEC) injury pathways in governing anti-TNF therapy effectiveness for ulcerative colitis. The project aims to identify predictive biomarkers in formalin-fixed, paraffin-embedded (FFPE) patient biopsies that...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $322,800 to Mayo Clinic to conduct a Phase 2B clinical trial on the effects of the compound HRX215 in promoting liver regeneration in patients undergoing major hepatectomy for colorectal cancer liver metastases or hilar cholangiocarcinoma. The project aims to evaluate whether HRX215, a highly selective small molecule MKK4 inhibitor, can stimulate faster liver regeneration in these patient populations compared to a placebo control group. The clinical trial will enroll 80 patients undergoing portal vein embolization prior to hepatectomy for colorectal cancer liver metastases, as well as 40 patients undergoing major hepatectomy for hilar cholangiocarcinoma. Volumetric CT scans will be used to measure the functional liver remnant size and regenerative response. The award period is from Aug 13, 2025 to Jun 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $322.8k | 8/12/25 |