This $681,496 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to determine the structures and channel properties of various polycystin protein complexes. The goal is to better understand their roles in sensory processes and develop polycystin-containing extracellular vesicles as a potential non-invasive biomarker for autosomal...
This $490,868 Project Grant was awarded on August 15, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to understand the mechanisms underlying autosomal dominant polycystic kidney disease (ADPKD), one of the most common life-threatening genetic diseases. The project will use mouse models to investigate how a second somatic mutation in an...
This federal Project Grant award of $504,621 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of intracellular cholesterol biosynthesis in regulating the progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD). The research aims to determine if reducing or enhancing cholesterol production impacts ADPKD cyst...
This federal Project Grant award, totaling $587,212, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, effective January 1, 2025, supports research to investigate the role of the CDKN1A (p21) protein in regulating cyst growth and development in polycystic kidney disease (PKD). The research aims to determine whether p21 is abnormally regulated as...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $135,582 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Oklahoma Health Sciences Center. The goal of this 1-year grant, with an award date of Sep 1, 2024, is to develop a single-cell atlas to better understand the molecular and cellular pathways in autosomal dominant polycystic kidney disease (ADPKD) patients and how they...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $640,001 to Yale University to conduct research on the polycystin-1 (PC1) protein and its role in autosomal dominant polycystic kidney disease (ADPKD). The key objectives are to: 1) determine whether a PC1 C-terminal fragment can suppress cyst formation and reverse established cystic...
This $728,513 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding a multi-year research project to develop and validate the use of quantitative susceptibility mapping (QSM) MRI for the detection and quantification of hemorrhagic cysts as a prognostic biomarker of kidney function decline in autosomal dominant polycystic kidney disease...
This $142,902 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to uncover the mechanisms by which the regulatory GTPase ARL13B drives the formation of kidney cysts in polycystic kidney disease (PKD). The award to Emory University, a major recipient of federal research funding, will support a 5-year research and training plan to: 1) identify critical amino...
The University of Pittsburgh received a $198,750 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a rapid, quantitative platform using yeast to classify how approximately 70 identified mutations in the polycystin-1 (PC1) protein disrupt channel activity with PC2. This research aims to provide new reagents and assays to the scientific and PKD (polycystic kidney disease) community to study the molecular defects of PC1 mutants. The...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $225,304 to Northwestern University to characterize the functional consequences of autosomal dominant polycystic kidney disease (ADPKD) disease-causing variants. The research project aims to implement a cell-free protein synthesis method to investigate the membrane...