This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of selective degradation strategies to target mutant transcription factors. The $253,500.00 award will fund experiments to design and test approaches to selectively degrade the mutant variant of the KLF1 transcription factor, which is implicated in...
This federal Project Grant award, valued at $949,056 and provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to study the functional roles of the DDX41 gene in the homeostasis of G-quadruplexes during erythropoiesis. The research, to be conducted by Northwestern University, will investigate how DDX41 loss of function leads to aberrant G-quadruplex...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to use a systems biology approach to identify gene regulatory networks related to hypoxia inducible factor-1a (HIF1a) in the kidney cortex and medulla. The $117,000 award, which runs from January 1, 2025 to December 31, 2026, will focus on validating predicted transcription factor...
This Project Grant award of $273,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at Rockefeller University to investigate the role of phospholipid homeostasis in cellular and organismal physiology. The key objectives are to: 1) study the influence of the choline transporter FLVCR1 on organismal metabolism and its potential as a therapeutic...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $696,870 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) from August 1, 2024 to May 31, 2028. The primary focus of this award is to conduct research on the functional characterization of the endothelial cell niche for hematopoietic stem...
This federal Project Grant award, totaling $465,155, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to understand how mutations in the SRCAP gene promote the development of therapy-related clonal hematopoiesis, a precursor to therapy-related myeloid neoplasms, a devastating complication of cancer treatment. The research will utilize a novel...
This $475,020 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the N-terminus of the GATA1 transcription factor in regulating erythropoiesis. The project aims to: 1) identify the cofactors recruited by the N-terminus to regulate erythropoiesis, and 2) explore the N-terminus' role in controlling...
This federal Project Grant award of $224,088.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the mechanisms of Notch signaling in intestinal stem cells. The key objectives are to: 1) define the Notch signaling niche for intestinal stem cells throughout development, and 2) investigate how intestinal stem cells provide...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $240,725 to fund research on how proinflammatory cytokines affect pancreatic beta-cell Golgi structure and function. The project aims to investigate the role of nitric oxide and the Golgi structural protein GRASP55 in mediating cytokine-induced Golgi remodeling, and the implications...
This $243,590 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at the University of Chicago to investigate the role of the protein BNIP3 in regulating lipid metabolism and fat accumulation in the liver. The research aims to elucidate the mechanisms by which BNIP3 promotes mitophagy (selective degradation of mitochondria) and...