Project Grant R01DK138205
Award Date
9/5/24
Completion Date
8/31/29
Dollars Obligated
$949K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60611, USA
Similar Awards
This $475,020 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the N-terminus of the GATA1 transcription factor in regulating erythropoiesis. The project aims to: 1) identify the cofactors recruited by the N-terminus to regulate erythropoiesis, and 2) explore the N-terminus' role in controlling...
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of selective degradation strategies to target mutant transcription factors. The $253,500.00 award will fund experiments to design and test approaches to selectively degrade the mutant variant of the KLF1 transcription factor, which is implicated in...
This Project Grant award of $1,560,024 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 supports research on the intracellular trafficking and signaling of the metabolite heme in myeloid cells. The primary awardee, Scripps Research Institute, will leverage mouse models, chemical tools, and new mouse mutants to reveal a molecular pathway for how heme signaling regulates the differentiation and function of macrophages under normal and disease...
This $188,538 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Northwestern University to develop predictive modeling of chromatin packing domains for personalized biomarker discovery in ulcerative colitis. The goal is to establish a framework linking transcriptomic states with chromatin structure to advance biomarker development. The research project...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $249,000 to the University of Chicago to investigate the role of m6A mRNA methylation in the aging of B-cells and its relationship to diabetes. The research aims to characterize the temporal m6A landscape of the aging B-cell, identify molecular targets of the m6A eraser ALKBH5...
This Project Grant award of $240,725.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at the University of Iowa to investigate how proinflammatory cytokines affect pancreatic beta-cell Golgi structure and function in the context of type 1 diabetes. The research aims to understand the role of nitric oxide and the Golgi structural protein GRASP55 in driving Golgi remodeling...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,170,271 to Northwestern University to conduct research on the regulation of bile acid metabolism by the X-box binding protein 1 (XBP1) pathway. The central hypothesis is that during cholestasis, hepatic XBP1 activation reduces bile acid synthesis and regulates bile acid metabolism by...
This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
This federal Project Grant award of $444,867.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research will use a novel mouse model to elucidate the pathological role of XBP1s in beta cell integrity under metabolic stress, in order to...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $161,922 to the Albert Einstein College of Medicine to elucidate the interplay between DDX41 and CUX1 mutations and their impact on hematopoiesis. The research will utilize zebrafish models and human induced pluripotent stem cells (iPSCs) to characterize changes in hematopoietic stem and progenitor cells, as well as differentiated progeny, under these...