This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $245,123 to support research on the role of vascular sympathetic neurons in brown adipose tissue and their impact on systemic metabolism. The project, led by The Trustees of Columbia University in the City of New York, aims to use novel genetic and chemogenetic tools, advanced...
This federal Project Grant award of $413,690 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to delineate the neuronal circuits and signaling pathways that regulate developmental timing in response to social cues in the model organism C. elegans. The research aims to identify how the nervous system non-autonomously regulates organismal growth and development, with the potential to alter...
The National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) awarded a $355,111 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Pennington Biomedical Research Center in Baton Rouge, Louisiana. The 5-year grant, running from August 1, 2024 to June 30, 2029, will fund research to better define the mechanisms of the glycophagy shunt and its role in cellular metabolism. The research aims to enhance understanding of glycogen metabolism,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $450,252 to Oklahoma State University to conduct research on glial cell dysfunction and its role in obesity-induced hypertension and sympathetic nervous system overactivity. The key objectives of the 5-year project are to: 1) determine the mechanistic role of senescent microglial cells and their secretory phenotype on sympathetic...
This Project Grant award in the amount of $1,130,886.00 was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The grant will fund research at The University of Texas Southwestern Medical Center on the molecular mechanisms underlying intracellular lipid sensing and metabolic regulation. Specifically, the project aims to define how the nuclear hormone receptor NHR-49 is activated and attenuated in...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $828,335 to the University of Chicago to investigate the roles of inhibitory and disinhibitory neural circuits in the formation, stabilization, and competition of neural assemblies in the cortex. The project aims to experimentally test theoretical...
This $379,823 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define the mechanisms driving novel cyclic nucleotide signaling pathways in immune defense. The principal investigator, Dr. Benjamin R. Morehouse, Ph.D., will use a combination of bioinformatic analysis, biochemical testing, and structural biology approaches to explore cyclic nucleotide signaling systems...
This federal Project Grant award, with the ID R35NS132231, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $885,128 grant supports research aimed at gaining a molecular-level understanding of the design principles governing somatosensation and nociception by membrane sensory receptor channels, as well as broader contextualization. The research, led...
This federal Project Grant award R35GM154966, totaling $1,112,418.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The overarching goal of this 5-year project is to identify specific loci involved in complex trait variation affecting fitness in natural populations. The work will integrate studies of tissue-specific assays of gene regulation, surveys in natural populations, and new...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $738,566.00 to The Salk Institute for Biological Studies to conduct research on defining the circuit mechanisms that regulate somatosensory feedback. The research aims to determine if similar inhibitory mechanisms exist across the body and somatosensory modalities to dynamically...