This federal Project Grant award of $622,003 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to characterize the role of pathogenic germline mutations in the progression of Barrett's esophagus to esophageal adenocarcinoma. The award aims to provide more precise risk estimates of germline alterations in the ATM and BRCA2 genes, assess the impact of...
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $243,750 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of the University of Pennsylvania. The grant will fund the development of novel methods to improve detection of mosaic chromosomal alterations (MCA) in non-neoplastic tissues like the kidney and blood. The project aims to create single-cell sequencing techniques and spatial...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of CD73 in esophageal epithelial homeostasis and its potential therapeutic implications for eosinophilic esophagitis (EoE). The $757,364 award to The Children's Hospital of Philadelphia Research Institute will support a 4-year research project to: 1)...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $516,648.00 to investigate the role of epigenetic memory in intestinal regeneration. The research aims to characterize how inflammatory exposure alters the epigenetic landscapes of intestinal stem cells and impacts their regenerative capacity. Key objectives include perturbing...
This Project Grant award, totaling $233,600.00 and spanning September 1, 2024 to June 30, 2027, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports high-throughput functional analyses of genetic drivers of inflammatory bowel disease (IBD), a debilitating condition characterized by chronic inflammation and erosion of intestinal functions. The...
This $594,956 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to determine the mechanisms underlying how esophageal stretch activates vagal afferent nerves. The key objectives are to identify the mechanosensitive receptors, such as Piezo channels, and voltage-gated sodium channels responsible for transducing esophageal...
This $1,558,188 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate how changes in transcription factor and heterochromatin states impact liver development, homeostasis, and regeneration. The primary awardee, The Trustees of the University of Pennsylvania, will use advanced in vivo imaging technologies and genetic...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $747,500.00 to support research on memory formation in the enteric nervous system (ENS). The project aims to build the tools required for studying the formation and meaning of ENS memories, and then use these tools in combination with various perturbations to transform the...
This $754,400 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The funding will support research by The University of Texas Southwestern Medical Center (UT Southwestern) to identify adaptive genetic pathways and understand how mutant clones expand within chronically damaged liver tissues, with the goal of developing therapeutic approaches...
This $477,151 Project Grant was awarded on September 1, 2023 by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI). The purpose of the grant is to study how neoplasia-derived extracellular vesicle microRNAs can promote DNA damage and carcinogenesis in Barrett's esophagus, with the goal of identifying novel targets for chemical ablation. The grant includes two sub-awards...