Project Grant R01DE035476
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $429,000 on June 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the effects of recurrent periodontitis on hematopoietic stem cell function. The research establishes a chronic periodontitis model to examine long-term effects on hematopoietic stem cells and defines the functional consequences of chronic periodontitis on these cells, accounting...
- The National Institute of Dental and Craniofacial Research awarded Regents of the University of Michigan $312,000 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate retinoic acid signaling in ameloblast differentiation during dental enamel formation. The research integrates single-cell RNA-sequencing data from 14 studies across mouse, rat, and human tooth development to determine ameloblast differentiation trajectories and elucidate the role...
- The National Institute of Dental and Craniofacial Research awarded the University of Texas Health Science Center at Houston $429,000 on July 16, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate how dietary composition influences Fusobacterium nucleatum physiology and virulence. The project will define the mechanism by which fruit peel extracts induce amyloid fibrils on F. nucleatum surfaces and re-examine the molecular model of amyloid genesis. The...
- The National Institute of Dental and Craniofacial Research awarded Loma Linda University $358,823 on September 11, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct structural-functional studies of gingipain biogenesis and localization in periodontitis research. The research addresses therapeutic gaps in managing periodontitis, a chronic disease linked to systemic diseases including atherosclerosis, rheumatoid arthritis, cancers, diabetes, and Alzheimer's...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $379,320 on September 11, 2025, under the Trans-NIH Research Support program (CFDA 93.310) to develop noninvasive quantitative ultrasound biomarkers and machine learning classifiers for detecting periodontal inflammation. The project establishes ultrasound-derived quantitative parameters and develops a machine learning classifier to characterize inflammatory conditions in periodontal...
- The National Institute of Dental and Craniofacial Research, an operating division of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $600,214 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to define the neuronal basis of odontogenic pain and identify targets for non-opioid analgesic development. The project, led by Dr. Joshua Emrick, investigates the cells, circuits, and behavioral...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $584,420 on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the cellular and genetic mechanisms underlying medication-induced osteonecrosis of the jaw (ONJ), a damaging condition of exposed and necrotic bone that occurs primarily in cancer patients taking high-dose bisphosphonates or anti-RANK ligand antibodies. The project will elucidate...
- The National Institute of Dental and Craniofacial Research awarded $234,000 to the University of Texas Health Science Center at Houston on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate decoy adhesion mechanisms by which the commensal bacterium Veillonella atypica shields oral epithelial cells from colonization and inflammatory damage by the pathogenic keystone species Porphyromonas gingivalis. The research dissects the molecular and...
- The National Institute of Dental and Craniofacial Research awarded Baylor College of Medicine $453,797 on June 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the structures and functions of natural products in periodontal disease. The funded research centers on a novel biosynthetic gene cluster found in clinical isolates of Porphyromonas gingivalis that appears to encode an antibiotic selective for other P. gingivalis strains and related oral...
- The National Institute of Dental and Craniofacial Research (NIDCR), a component of the Department of Health and Human Services National Institutes of Health, awarded Loma Linda University $631,170 on July 21, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct structural-functional studies of gingipain biogenesis and localization in the context of periodontitis and Porphyromonas gingivalis pathogenesis. The project will expand understanding of...
The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $583,620 on August 21, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to engineer transfer RNA-derived small RNAs (tsRNAs) as species-specific antimicrobial agents targeting oral pathobionts. The funded work develops chemically modified tsRNAs to suppress dental pathogens including Fusobacterium nucleatum, Porphyromonas gingivalis, and Treponema denticola while sparing commensal oral bacteria. The project builds on the recipient's discovery that host-derived tsRNAs selectively enter pathogenic bacteria and inhibit growth. Two complementary aims address both mechanism and translation: the first dissects molecular determinants of species-selective uptake and inhibition by mapping tsRNA nucleotides and conserved protein residues and testing isoprenyl-histidyl-tRNA synthetase as a downstream mediator of translational attenuation; the second optimizes tsRNAs with strategic RNA modifications to enhance nuclease resistance, uptake, and potency while preserving target recognition elements. The work will quantify efficacy, specificity, and safety across oral pathobiont strains. Performance occurs at the University of Michigan in Ann Arbor, Michigan. The period of performance runs through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $583.6k | 8/24/26 |