Project Grant R01DE034974
- This federal Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to delineate molecular variations within head and neck squamous cell carcinoma (HNSCC) tumors based on distinct histopathologic features and employ machine learning techniques to construct a predictive model using molecular data. The total funding amount is $252,915, awarded to Rutgers, The State University of...
- This federal Project Grant award of $642,488.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to determine if targeting the MARCHF8-autophagy pathway can activate antitumor immunity and remodel the tumor microenvironment in HPV-positive head and neck squamous cell carcinomas (HPV+ HNSCCs). The research, conducted by the collaborative partnership of Henry Ford Health and...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will advance the understanding of the genomic basis for oral diseases such as dental caries and periodontitis. The $673,091 award to the University of Pittsburgh will support the formation of a research consortium of over 800,000 participants across 27 studies. The key activities include: Conducting the largest genome-wide...
- This $433,125 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to develop small molecule inhibitors targeting HPV-induced oropharyngeal cancers. The primary goals are to: 1) Create tongue carcinoma cell lines differing in HPV status to enable screening, 2) Screen small molecule libraries to identify drug candidates that specifically induce death of HPV-positive cancer cells, and...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $141,762 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The grant supports a 19-month research project investigating the mechanism by which the E3 ubiquitin ligase MARCHF8 promotes immune evasion in human papillomavirus (HPV)-positive head and neck squamous cell carcinomas....
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $427,208 Project Grant to Virginia Commonwealth University (VCU) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant, with a period of performance from Aug 12, 2025 to May 31, 2030, supports research to develop a novel immunotherapeutic agent, called hFLAGRP170, to improve the treatment of head and neck squamous cell carcinoma (HNSCC), including oral cancer. The project aims to evaluate the...
- The Project Grant award of $320,000 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to understand the role of the tumor immune microenvironment in radioresistance and whether PARP inhibitors can overcome this resistance in head and neck squamous cell carcinoma (HNSCC). The grant supports the development of a novel genetically engineered mouse model to study the KEAP1/NRF2 signaling pathway and its...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $315,000 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to The Ohio State University. The funding supports research to develop novel antibody therapeutics targeting the HPV oncoproteins E6 and E7, which are key drivers of head and neck cancers caused by human papillomaviruses (HPV). The research aims to generate HPV oncoprotein-targeting dimeric IgA antibodies and assess their...
- The Project Grant award "DISSECTING CCL5 CONTRIBUTION TO ANTIGEN SPECIFIC T CELL RESPONSES IN HEAD AND NECK CANCERS" is funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The $3,742,682 award supports research aimed at understanding the role of the CCL5 chemokine in shaping the tumor-specific T cell immune response in head and neck cancers. The research will leverage...
- This federal Project Grant award of $716,123.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research at H. Lee Moffitt Cancer Center and Research Institute to develop non-invasive liquid biopsy tests for prognostic prediction in head and neck squamous cell carcinoma (HNSCC). The key objectives are to 1) validate, discover and optimize liquid biopsy tests based on analysis of...
This $1,899,042 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), to the University of Pittsburgh for the project "ANALYSIS OF HIGH DIMENSIONAL GENOMIC DATASET TO REVEAL MECHANISTIC INSIGHTS ON DIVERGENT OUTCOMES OF HEAD AND NECK CANCER USING SYSTEM BIOLOGY MODELING COUPLED WITH EXPERIMENTAL VALIDATION". The project aims to analyze existing genomic datasets of head and neck squamous cell carcinoma (HNSCC) to uncover new mechanisms underlying the divergent clinical outcomes between HPV-positive and HPV-negative HNSCC subtypes. This research will provide insights to inform the design of personalized therapies and combination treatment strategies targeting the specific characteristics of each HNSCC subtype. The grant period runs from Sep 19, 2025 to Sep 18, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 9/19/25 |