Project Grant R01DE034775
- Federal Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $716,123 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective September 8, 2025 through May 31, 2030. The award supports research focused on developing ultrasensitive detection methodologies for circulating DNA methylation biomarkers in head and neck squamous cell...
- Federal Grant Award Summary The University of Kansas Medical Center Research Institute, Inc. received a $426,250 Project Grant award dated August 14, 2025, from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The two-year research initiative, concluding August 13, 2027, focuses on characterizing two endopeptidases (SEPM homologs) encoded by Streptococcus sanguinis, an oral commensal bacterium capable of...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Missouri System $249,000 under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period July 1, 2025 through June 30, 2028. The project, titled "Novel OrganoPET Assay for Precision Therapy of Head and Neck Cancer," develops innovative diagnostic and screening methodologies to advance personalized treatment approaches for head and neck...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR), under its Oral Diseases and Disorders Research program (CFDA 93.121), awarded Dana-Farber Cancer Institute, Inc. a $3.74 million Project Grant effective August 21, 2025, through August 20, 2029. This research initiative, titled "Dissecting CCL5 Contribution to Antigen Specific T Cell Responses in Head and Neck Cancers," involves translational and clinical research to advance...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $451,000 to The Regents of the University of California, San Francisco under the Oral Diseases and Disorders Research program (CFDA 93.121) on August 8, 2025, for a two-year project concluding August 7, 2027. The award funds the development and characterization of metastatic MYB-NFIB fusion adenoid cystic carcinoma (ACC) cell line models to advance understanding of this rare but aggressive...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Washington University a $427,625 Project Grant effective February 6, 2026, through February 5, 2028, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports research and development of radiation-guided theranostic agents to improve detection, treatment monitoring, and therapeutic outcomes for head and neck squamous cell carcinoma (HNSCC). Specifically,...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded the University of Michigan a Project Grant totaling $219,660 (awarded January 1, 2029) under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research investigating the evolution of pro-tumoral myeloid cells during the initiation of oral cancer. The research focuses on understanding how SOX2-driven genetic alterations in human papillomavirus-negative head and neck squamous cell...
- Federal Grant Award Summary Virginia Commonwealth University received a $427,208 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 12, 2025, with a completion date of May 31, 2030. The award supports research into a novel immunotherapeutic agent (hFlagRP170) designed to improve treatment outcomes for head and neck squamous cell carcinoma (HNSCC), including oral cancer....
- Federal Grant Award Summary The University of Arkansas for Medical Sciences received a $306,000 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 1, 2025 through July 31, 2027. The award supports research investigating the role of macrophage migration inhibitory factor (MIF) signaling in Kaposi's sarcoma-associated herpesvirus (KSHV)-related malignancies, including...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant totaling $129,289 to Stanford University, effective August 2, 2025, through July 31, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative focuses on developing and evaluating lysosome-targeting chimeras (LYTACs)—a novel class of protein degraders—to enhance immunoradiotherapy treatments for head and neck cancer. The project...
The University of Kansas Medical Center Research Institute, Inc. received a $693,365 Project Grant from the National Institute of Dental and Craniofacial Research under the Oral Diseases and Disorders Research program (CFDA 93.121) effective March 1, 2026, through February 28, 2031. The award supports basic and translational research investigating the role of MAPKAPK2 (MK2) protein in head and neck squamous cell carcinoma (HNSCC) cell migration, invasion, and metastases. The research aims to identify molecular mechanisms by which MK2 pathway activation contributes to therapy failure and regional/distant disease progression in HNSCC patients. The project will deliver research findings through three specific aims: (1) examination of how tumor MK2 regulates FAK-ITGB4 mediated tumor cell migration and invasion using novel biotin-ligation proximity labeling assays to identify MK2-specific protein-protein interactions; (2) investigation of how radiotherapy efficacy is affected by tumor-intrinsic MK2 inhibition versus inhibition of MK2 in both tumor cells and the microenvironment; and (3) additional research activities designed to understand molecular switches controlling metastatic progression. These research outputs are intended to inform strategies for halting cancer cell migration and invasion, thereby improving radiotherapy effectiveness and long-term survival outcomes for HNSCC patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $693.4k | 2/17/26 |